| The development of preclinical imaging using micro-MR, CT, PET, SPECT, optical and ultrasound technologies has created a new paradigm for imaging in the laboratories of biomedical researchers. Once considered a luxury for isolated multi-user centres, micro-imaging platforms are now becoming mainstream in bioresearch where quantitative in vivo imaging measurements of biomarkers and other endpoints are becoming a requirement of these investigations. Micro-ultrasound has come a long way from its inception in the mid nineteen nineties. This paper will detail the progression of preclinical micro-ultrasound from mechanical to array based imaging systems. The current state of the art of the technologies and applications will be highlighted and future directions will be discussed. |