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October 28, 2011

Mtg: Unleashing the Power of Integrated Circuits for DNA Sequencing

by @ 6:34 am. Filed under ALL, BioEngineering, Optics/Displays, Semiconductors

WEDNESDAY November 16, 2011
SCV Engineering in Medicine and Biology Chapter
Speaker: Stefan Roever, CEO & Founder, Genia Technologies, Inc.
Time: Optional dinner at Stanford Hospital Cafeteria, 6:15 PM; Presentation at Med School at 7:30 PM
Cost: none
Place: Presentation at Room M-114, Stanford University Medical School, Stanford
RSVP: not required

There is no debate that genetic information is needed to truly realize the promise of personalized medicine.? The problem is that todayâ??s DNA sequencers cost anywhere from $50K – $1M, rely on complicated optics, and utilize a complex workflow that does not lend itself to clinical utility.
Genia is using standard semiconductor technology to enable massively parallel, single molecule DNA sequencing.? The company has developed a versatile nanopore-based platform which allows for single molecule, electrical, real-time analysis without the need for enzymes, complicated optics, labels, amplification, or fluidics.? Geniaâ??s key proprietary innovations around the nanopore allow single molecules of single stranded DNA to move through the pore slowly so the sequence can be measured accurately.? The sensor itself is truly transformative and allows very small electrical signals (~0.2 pA current levels) to be seen high above the noise floor, which is one of the issues other nanopore companies are currently struggling with.? The data show that with highly accurate analog electronics and clever data analysis techniques, single base discrimination is possible, and adequate SNR can be reached to perform DNA sequencing.
Geniaâ??s mission is to unify Mooreâ??s Law with biotechnology to make genetic information universally available.? By developing a true integrated circuit on standard semiconductor process technology, Genia brings Mooreâ??s Law to the biological world to revolutionize the world of DNA sequencing.

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