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February 28, 2014

Mtg: Nanophosphors in Cancer Diagnosis, Therapeutics and Drug Delivery

by @ 1:54 pm. Filed under ALL, BioEngineering, NanoEngineering

TUESDAY March 18, 2014
SCV Nanotechnology Chapter
– scintillator materials, X-ray luminescence, imaging …
Speaker: Dr. P. R. Ravilisetty, President, Specialty Phosphors Inc.
Time: Networking, Pizza at 11:30 AM; Presentation at Noon
Cost: IEEE Members $5; Non-members $10
Place: Texas Instruments Auditorium, 2900 Semiconductor Dr., Santa Clara
RSVP: from website

Mammography is considered to be the best tool for the detection of breast cancer, and high-resolution images can detect cancer more accurately than other systems, particularly with computer-aided diagnosis (CAD) systems. Current digital mammography systems use needle shape CsI:Tl phosphor pixels <100 ?m in size.  The stability and life span of these phosphor needles are limited due to their hygroscopic and fragile nature. Our approach to avoid current limitations in digital mammography is to grow micron-size pillars of very stable scintillator materials using novel nanophosphors.
Photodynamic therapy (PDT) is currently used clinically where a photosensitizer such as Photofrin® is activated with laser light to produce oxygen radicals that kill cancer cells. Visible light only penetrates few millimeters into tissue.  IR light penetrates much deeper, but does not activate photo sensitizers.  Upconverting phosphors (UCPs) absorb infrared photons and emit visible photons. Due to low conversion efficiency, UCPs do not deliver enough visible light.  X-ray excitable nanophosphors are good candidates to deliver higher flux visible light to sensitize PDT drug. Currently, we are investigating the possibility of adopting inorganic nanophosphors as a biological contrast agent for medical imaging in X-ray/optical combo.  We are also working on X-ray luminescence computed tomography (XLCT), a new molecular imaging modality with medical research groups at Stanford University.  This combined modality may yield an increase in the utility of omnipresent X-ray imaging by enabling concurrent molecular imaging.   Nanophosphors with magnetic properties are being explored at SPI in drug delivery.
Nanophosphors synthesis, characterization, and possibilities of using in early detection of breast cancer, X-ray PDT, medical imaging in a combined X-ray/optical instrument and drug delivery will be presented.


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