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November 24, 2014

Mtg: Lab-on-Chip Technologies Beyond the Diffraction Limit: Ebola Detection and Cancer Diagnostics

by @ 1:33 pm. Filed under ALL, BioEngineering, NanoEngineering, Optics/Displays
 

WEDNESDAY January 28, 2015
SCV MEMS and Sensors Chapter
– nanophotonics, tranformative, fluidics, in-vitro diagnostics …
Speaker: Professor Ahmet Ali Yanik, UC Santa Cruz
Time: Networking and pizza at 7:15 PM; Presentation at 7:45 PM
Cost: $5 donation for food
Place: Texas Instruments Building E Conference Center, 2900 Semiconductor Dr., Santa Clara
RSVP: not required
Web: sites.ieee.org/scv-mems

Nanophotonics is opening a myriad of unprecedented opportunities for biomedical applications by localizing light beyond the diffraction limit and dramatically boosting the light-matter interactions at nanoscale dimensions.  In this talk, I will introduce a number of tranformative technologies based on nanoscale control of light and fluidics on a chip.  I will show how to overcome some of the fundamental limitations of the state of art techniques used in vitro diagnostics, which makes up a $10B global market.  First, an ultrasensitive detection technology with detection limits surpassing the gold standard surface plasmon resonance (SPR) sensors will be introduced.  Practical applications of this technology allowing million-fold enhanced multiplexing capabilities with minute sample volumes will be shown. Using a bottom-up approach, I will merge nanofluidic and nanophotonic technologies at sub-wavelength dimensions to break the diffusion barrier. For point-of-care applications, a novel sensing scheme enabling label-free detection of biomarker proteins â??with the naked eyeâ? will be introduced.  Real-world applications of these optofluidic-plasmonic sensors for rapid and reliable detection of whole viruses from biological media will be demonstrated. I will extend this nanofluidic approach to a micro-nano cross flow scheme for isolation of rare circulating tumor cells (CTCs) for cancer diagnostics and prognosis.  Potential implications of this technique for the analysis of single tumor cells and their metastatic potential will be discussed.
For conformational analysis of proteins at few molecule levels and in vivo real time cancer biopsy applications, I will introduce an ultrasensitive infrared (IR) nanospectroscopy technique allowing 100,000 fold signal enhancements in vibrational signatures of proteins. Using collective excitation of these plasmonic nanoantenna arrays, unprecedented near field enhancements and record low zepto-mole detection limits will be demonstrated.  I will discuss potential applications of this technology for pharmaceutical applications such as small drug molecule-protein interactions. This nanospectroscopic technique will be integrated onto optical fiber surfaces to achieve real-time cancer biopsy in the human body.  Finally, I will introduce a novel absorption spectroscopy technique based on asymmetric Fano resonances in metal-materials for complete and simultaneous analysis of protein-protein interactions and their folding states.

20150128scv

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