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IEEE Virginia Mountain Section

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Thursday, October 16, 2014 in Roanoke

Implantable Microsystems
for Quantitative Measurement of Biomolecules
for the Management Hemorrhaging Patients

Anthony Guiseppi-Elie, Sc.D.

Center for Bioelectronics, Biosensors and Biochips (C3B)
Clemson University

Slides of Dr. Guiseppi-Elie's talk (PowerPoint)_

We have developed a minimally-invasive, implantable, point-of-care (POC), bioanalytical microsystem for rapid deployment and continual monitoring of intramuscular glucose and lactate via dual responsive amperometric enzyme biosensors. This engineered microsystem is being developed for use by first responders to allow multi-analyte monitoring of key metabolites of hemodynamic stress useful in the management of trauma induced hemorrhage.

Continued high morbidity and complications due to trauma related hemorrhage underscores the fact that our understanding of the detailed molecular events of trauma are inadequate to bring life-saving changes to practice. The current gold standard of care in trauma diagnostics relies strongly on vital signs rather than on metabolic biomarkers.

No vital sign has yet to be proven effective as an independent predictor of trauma severity. Implantable point-of-care (POC) analytical microsystems are being developed for use by first responders to allow for rapid, continual monitoring of glucose and lactate via dual responsive amperometric enzyme biosensors, tissue acidosis via impedimetry, VO2 via voltammetry and K+ via potentiometry. Multi-analyte monitoring biosensors have the potential to explore areas still unexplored in the realm of trauma physiology. Fully implantable bioanalytical ASICs that continually measure and report are poised to be next big thing in inner space.

Anthony Guiseppi-Elie is Professor of Chemical and Biomolecular Engineering, Professor of Bioengineering, Professor of Electrical and Computer Engineering and Director of the Center for Bioelectronics, Biosensors and Biochips at Clemson University. He is Founder and Scientific Director of ABTECH Scientific, Inc., a near-patient biomedical diagnostics company located in the Biotechnology Research Park, Richmond, Virginia.

He holds the Sc.D. in materials science and engineering from MIT, the M.Sc. in chemical engineering from the University of Manchester Institute of Science and Technology (UMIST) and the B.Sc. (First Class Honors) with majors in Analytical and Applied Chemistry from the University of the West Indies (UWI).

Tony has spent 15 years in intrapreneurial and entrepreneurial industrial research and product development before becoming a full professor of Chemical and Life Science Engineering and of Emergency Medicine at VCU/MCV in 1998. In 2006, he joined Clemson as the Dow Chemical Professor. His research interests are in engineered bioresponsive systems in the service of human health and medicine (136 papers, 3681 citations, h-index = 31).

He was the 2014 Visiting Distinguished Professor of Industrial Bioelectronics at l'Ecole des mines d'Alès, the 2013 Avis Professor in Pharmaceutics at the University of Tennessee Health Sciences Center, a 2012-2013 IEEE-EMBS Distinguished Lecturer, a 2012 Microsystems Distinguished Lecturer at the University of Maryland, a recipient of the 2003 “Pioneers in Biomedical Engineering” Lecture Award from Purdue University and an Invited Lecturer in the MIT Program in Polymer Science and Technology.

Tony is Editor-in-Chief of Bioengineering, and Associate Editor of Biomedical Microdevices. He is an AIMBE Fellow, a Fellow of the Royal Society of Chemistry, a Sr. member of IEEE, a lifetime member of AIChE and holds memberships in AAAS, ACS, MRS and BMES. At Clemson Tony teaches engineering materials, biological transport phenomena, biomolecular engineering, biosensors and bioelectronics, and nanobiotechnology.

Meeting Details:
Thursday, October 16, 2014
Social: 6:30 PM
Dinner: 7:00 PM
Talk: 8:00 PM

Please let us know if you have any dietary restrictions (vegetarian, dairy or gluten allergy, etc)

Holiday Inn – Roanoke

3315 Ordway Drive NW
Roanoke, VA 24017

Directions to Holiday Inn – Roanoke:
From I-581, take exit 3W Hershberger Rd. Turn right at the first traffic light (near WDBJ-7 TV studios and Zaxby’s Chicken) onto Ordway Drive. Continue past Big Lots and the Holiday Inn is on the right.

Continuing Education

One Continuing Education Credit will be awarded for this meeting. Please see Joel Donahue at the meeting to sign up for the credit.


RSVP by 5 PM, Monday, October 13, 2014.
Please specify the number of attendees and any dietary needs/restrictions to George Williams, Vice-Chairman,

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The Virginia Mountain Section (VMS) of the IEEE has been serving members in the Southwest corner of the Commonwealth of Virginia since 1949.

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