Short Courses for the 2003 IEEE International Ultrasonics Symposium

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Course #1: Fundamentals of Ultrasonic Waves
Course #2: Medical Ultrasound Transducers
Course #3: Recent Trends in Beamformation in Medical Ultrasound
Course #4: Cancelled
Course #5: Micromachined Ultrasonic Sensors and Actuators
Course #6: Ultrasound contrast agents: Theory and experimental results.
Course #7: Synthetic Aperture Ultrasound Systems
Course #8: Finite Element Modeling of Electromechanical Transducers
Course #9: Elasticity Imaging


Course #1: Fundamentals of Ultrasonic Waves
Instructor: David Cheeke
Concordia University
Montreal, Quebec, Canada

Time: 8:00 am - noon, October 5, 2003.

Abstract: The objective of this course is to provide a sound physical basis for understanding the propagation of acoustic waves in solids. The course is aimed at newcomers to the field with at least BSc level in Physics or Engineering and also to those with experience in practical ultrasonics but who lack a theoretical basis. The material is divided into four equally balanced parts. The first deals with the propagation of bulk waves in infinite media, the wave equation, and the relation of acoustic properties to the appropriate material parameters. This is followed by a detailed treatment of the solid-liquid interface, with emphasis on the partial reflection and transmission of acoustic waves. This leads into a discussion of surface acoustic (Rayleigh) waves in the third section. These concepts are extended in the final section to a consideration of guided waves (Lamb, Love, SH, etc.) in various multilayer structures. Where appropriate, applications of these modes will be discussed.

David Cheeke received the Bachelors and Masters degree in Engineering Physics from UBC, Vancouver, in 1959 and 1961, respectively, followed by the PhD in Low Temperature Physics from Nottingham University in 1965. He then joined the Low Temperature Laboratory, CNRS, Grenoble, also as a Professor of Physics at the University of Grenoble. In 1975, he moved to the Université de Sherbrooke, Canada, where he set up an ultrasonics laboratory, specialized in physical acoustics, acoustic microscopy, and acoustic sensors. In 1990, he joined the Physics Department at Concordia University, Montreal, where he is Head of an Ultrasonics Laboratory and was Chair of the Department 1992-2000. He has published over 120 papers on various aspects of ultrasonics. He is senior member of the IEEE, a member of the ASA, and an Associate Editor of the IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

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Course #2 Medical Ultrasound Transducers
Instructors: Douglas G. Wildes and L. Scott Smith
GE Global Research Center
Niskayuna, NY

Time: 8:00 am - noon, October 5, 2003.

Abstract: This course will provide an introduction to the design, fabrication, and testing of medical ultrasound transducers. Starting from an overview of the basic types of phased-array transducers (linear, convex, sector), we will discuss how the design for a probe is derived from its target application and how equivalent-circuit, finite-element, and acoustic field models can be used to optimize the design and accurately predict performance. A discussion of the structure of an ultrasound probe will lead to a survey of the different types of materials used in probes and their critical properties. Typical fabrication processes will be introduced and common problems in probe manufacturing will be summarized. Methods for evaluating completed transducers will be discussed. We will conclude with some examples of newer probe technology, e.g. multi-row arrays, single crystal piezoelectrics and cMUT transducers, and will discuss performance advantages and fabrication difficulties which may be associated with each.

Douglas G. Wildes is a physicist with GE Global Research. He earned an A.B. in physics and mathematics from Dartmouth College and a Ph.D. in low-temperature physics from Cornell University, then joined GE in 1985. Since 1991, Dr. Wildes' research has focused on aperture design, fabrication processes, and high-density interconnect technology for multi-row transducers for medical ultrasound. The results of his work are reflected in GE's growing line of Matrix Array probes, for which he has received several GE awards. Dr. Wildes has 16 issued patents and 18 external publications. He is a member of the American Physical Society and the IEEE.

L. Scott Smith is a physicist with GE Global Research. He earned B.S. and Ph.D. degrees in physics from the University of Rochester and the University of Pennsylvania respectively. Joining GE in 1976, he developed phased array probes for medical ultrasound. More recently, he examined novel probe materials and led projects on pediatric endoscopes and adaptive acoustics. Dr. Smith has 32 issued patents and over 30 refereed publications. He is a member of the American Physical Society and a Senior Member of the IEEE where he serves as Vice Chair for Transducers and Transducer Materials on the Ultrasonics Symposium's Technical Program Committee.

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Course 3: Recent Trends in Beamformation in Medical Ultrasound
Instructor: Kai E. Thomenius
General Electric's Corporate R&D
Niskayuna, NY

Time: 8:00 am - noon, October 5, 2003.

Abstract: The goal of this short course is to review analytical methods used in developing the design of a typical beamformer in use in diagnostic ultrasound today. Two specific methods, angular spectrum and spatial impulse response, will be discussed in some detail. The key points to be covered deal with methods of analysis of arrays and beamformers, the interaction of transmit and receive beams with clinically relevant targets, and how this interaction is used in image formation. The means by which these analytical methods contribute to a beamformer design and the trade-offs involved are reviewed. The techniques developed for such analysis will be applied to current topics involving beamformation such as elevation focusing, sparse arrays, harmonic imaging, and phase aberration correction. Heavy use of graphical techniques will be made to illustrate the concepts.

Kai E. Thomenius is the Manager for the Ultrasound Program at General Electric's Corporate R&D facility in Niskayuna, NY. Previously, he has worked at ATL Ultrasound, Inc. and Interspec Inc. as well as several other ultrasound companies. Dr. Thomenius' academic background is in electrical engineering with a minor in physiology; all of his degrees are from Rutgers University. His current interests are in beamformation, propagation of acoustic waves in inhomogeneous media, generation of harmonic energy during acoustic propagation, the potential of bioeffects due to those acoustic beams, and retrieval of additional diagnostic information from the echoes that arise from such beams.

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Course #4: Recent Advances in Acoustic Microscopy
  Course #4 has been cancelled.
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Course #5: Micromachined Ultrasonic Sensors and Actuators
Instructors: Amit Lal
Cornell University
Ithaca, N.Y.

Richard M. White
University of California
Berkeley, CA

Time: 1:00 pm - 5:00 pm, October 5, 2003

Abstract: The goal of this course is to introduce the fundamentals of micromachining and the way they affect the design and performance of ultrasonic sensors and actuators. The first part (~1.5 hours) of this course will cover established micromachining techniques, such as bulk micromachining and surface micromachining on silicon. It will also cover new techniques such as XeF2 etching and PDMS soft micromachining. The relevant acoustic and ultrasonic properties of materials used in MEMS will be discussed for predictable device design. In the remaining time, the following topics will be discussed with the help of case studies: (1) Electrostatic actuation of micromachined membranes: Nonlinearities and effective electromechanical coupling, (2) Comparison of PZT and thin-film piezoelectric actuation of silicon bulk and surface micromachined structures: silicon horn design, microphones, speakers, impact/spalling actuation of MEMS (3) Flexural plate waves and bulk waves in micromachined devices: the role of internal stresses and material properties on waves, (4) Nonlinear ultrasound in microfluidic devices.

Amit Lal is an assistant professor of electrical and computer engineering at Cornell University. He received his Ph. D. in electrical engineering from the University of California, Berkeley in 1996, and the B.S. degree from the California Institute of Technology in 1990. He was at the University of Wisconsin-Madison as an assistant professor from 1998-2002. Amit Lal is the leader of the SonicMEMS group at Cornell University, which focuses on ultrasonics, micromachining, modeling of piezoelectric systems, and design and analysis of integrated circuits. He has published papers on ultrasonic sensors and actuators at conferences in ultrasonics and micromachining. He serves on the Technical Committee on Physical Acoustics in the IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society. He holds patents on micromachined acoustic sources/receivers, and silicon-based high-intensity ultrasonic actuators. He is also the recipient of the NSF CAREER award for research on applications of ultrasonic pulses to MEMS.

Richard M. White is a professor of electrical engineering and computer sciences at the University of California, Berkeley. He is also a founding co-director of the Berkeley Sensor & Actuator Center, an NSF/Industry/University Cooperative Research Center. White received his university education at Harvard, completing the Ph.D. in applied physics. After five years at the General Electric Microwave Laboratory in Palo Alto, he joined the faculty of the University of California at Berkeley. There he has been primarily concerned with teaching and research in solid-state electronics, with particular emphasis in ultrasonic and sensors.

White's publications and patented inventions concern sensors, ultrasonic phenomena and devices, thermoelastic effects and microwave electronics. He has co-authored three books: Electrical Engineering Uncovered, Prentice-Hall, 1997 (an introductory text); Acoustic Wave Sensors, Academic Press, 1997 (a reference book); and Solar Cells: From Basics to Advanced Systems, McGraw-Hill, 1984 (a reference and text). He is an IEEE Fellow, recipient of the IEEE Cledo Brunetti award and the Cady award, a Guggenheim fellowship, and the IEEE Society's Achievement Award for contributions to the field of ultrasonics in photoacoustics, surface acoustic wave devices, and sensors. In 1994 White was elected to the National Academy of Engineering and made a Fellow of the American Association for the Advancement of Science, and in 1996 he was made a Chancellor's Professor at Berkeley.

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Course #6: Ultrasound contrast agents: Theory and experimental results.
Instructors: Nico de Jong
Erasmas University
Rotterdam, the Netherlands

Michiel Versluis
University of Twente
Enschede, The Netherlands

Time: 1:00 pm - 5:00 pm, October 5, 2003

Abstract: The course consists of 6 mean topics:
a) First an overview will be presented of the (clinical and pre-clinical available) contrast agents, including the properties and characteristics of the gas inside the bubble and the shell surrounding it.
b) Models of the behavior of small bubbles in a ultrasound field will be discussed. Simple models based on a one dimensional mass-spring system and more complicated models including gas and shell properties.
c) Experimental ultrasound methods for UCA will be presented for characterizing the bubbles in a UCA, like harmonic and subharmonic scattering, absorption and attenuation. Also the influence of ambient pressure, temperature and gas concentration will be discussed.
d) Experimental optical methods for characterizing individual bubbles.
e) Imaging methods for contrast agents, like fundamental, harmonic, subharmonic and superharmonic and multi-pulse methods like pulse inversion, power modulation etc. and new methods like chirp excitation.
f) Ultrasound mediated drug delivery: Interaction between mammalian cells and ultrasound in the vicinity of bubbles will be discussed.

Nico de Jong graduated from Delft University of Technology, The Netherlands, in 1978. He got his M.Sc. in the field of pattern recognition. Since 1980, he has been a staff member of the Thoraxcenter of the Erasmus University Medical Center, Rotterdam, The Netherlands. At the Dept. of Biomedical Engineering, he developed linear and phased array ultrasonic probes for medical diagnosis, especially compound and transesophageal transducers. In 1986 his interest in ultrasound applications shifted toward the theoretical and practical background of ultrasound contrast agents. In 1993 he received his Ph.D. for "Acoustic properties of ultrasound contrast agents." Currently he is interested in the development of 3-D transducers and fast framing camera systems. De Jong is the project leader of STW and FOM projects on ultrasound contrast imaging and drug delivery systems. Together with Folkert ten Cate, MD, he is organizer of the annual European Symposium on Ultrasound Contrast Imaging, held in Rotterdam and attended by approximately 175 scientists from all over the world.

Michel Versluis graduated in Physics in 1988 at the University of Nijmegen, the Netherlands, with a special interest in Molecular Physics and Astrophysics. Later, he specialized in the application of intense tunable UV lasers for flame diagnostics resulting in a successful defense of his PhD thesis in 1992. Michel Versluis is now a lecturer at the University of Twente, the Netherlands, in the Physics of Fluids group working on the experimental study of bubbles and jets in multiphase flows and granular flows. He also works on the use of microbubbles as a tool for medical diagnosis and therapy. Dr. Versluis teaches various courses in Fluid Mechanics, one of them focusing on the physics of bubbles.

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Course #7: Synthetic Aperture Ultrasound Systems
Instructor: Jørgen Arendt Jensen, Svetoslav I. Nikolov and Kim L. Gammelmark Technical University of Denmark Lyngby, Denmark

Time: 6:00 pm - 10:00 pm, October 5, 2003

Abstract: The objective of this course is to give a basic introduction to synthetic aperture (SA) ultrasound systems. The course is divided into three parts. First the basics of SA data acquisition and beamformation are described, when synthesizing either the transmitting or receiving aperture. Equations for the obtainable resolution and side lobe levels are given, and the compromise between number of emissions and resolution are explained. The second part describes the methods implementation for clinical imaging. Issues regarding signal-to-noise ratio, the use of coded excitation and aspects of focusing will be explained. The concept of recursive imaging will be introduced, and it will be shown how very fast imaging in two and three-dimensions can be obtained. The final part of the course describes velocity imaging using SA techniques. It is shown how SA systems can acquire data suitable for flow imaging, and that many of the problems encountered in current flow systems can be solved using SA imaging. This includes problems with stationary echo canceling, limited precision, and finding the correct velocity magnitude without angle correction.

The course is intended for Ph.D. students and researchers interested in the signal processing involved in synthetic aperture ultrasound system for two and three-dimensional imaging for visualizing both anatomy and the blood flow in the human body.

Jørgen Arendt Jensen earned his Master of Science in electrical engineering in 1985 and the Ph.D.degree in 1989, both from the Technical University of Denmark. He received the Dr.Techn. from the university in 1996. He has published a number of papers on signal processing and medical ultrasound and the book "Estimation of Blood Velocities Using Ultrasound", Cambridge University Press in 1996. He has been a visiting scientist at Duke University, Stanford University, and the University of Illinois at Urbana-Champaign. He is currently full professor of Biomedical Signal Processing at the Technical University of Denmark at the Ørsted*DTU and head of Center for Fast Ultrasound Imaging. He has given courses on blood velocity estimation at both Duke University and University of Illinois and teaches biomedical signal processing and medical ultrasound imaging at the Technical University of Denmark. His research interest are currently focused on fast ultrasound imaging using synthetic aperture techniques for anatomic and flow imaging.

Svetoslav Ivanov Nikolov got his Master of Science in electrical engineering and Master of Business and Administration in international business relations from the Technical University, Sofia in 1996 and 1997, respectively. In 2001 he got a Ph.D. degree from the Technical University of Denmark, Lyngby. His dissertation explored approaches for synthetic aperture tissue and flow imaging and their applicability for real-time 3D imaging. He is currently an assistant professor at the Technical University of Denmark at the Ørsted*DTU, where he teaches courses in digital design and software development. His research interests are currently focused on ultrasound 3D real time imaging.

Kim L. Gammelmark was born in Fakse, Denmark on May 1st, 1975. He received his M.S. degree in Electrical Engineering from the Technical University of Denmark, Kgs. Lyngby, Denmark, in August 2001. He is currently a Ph.D. student in Biomedical Engineering at the Ørsted*DTU department at the Technical University of Denmark. His major research interests are the application of synthetic aperture techniques in medical ultrasound imaging, and synthetic aperture radar techniques.

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Course 8: Finite Element Modeling of Electromechanical Transducers
Instructor: Reinhard Lerch and Manfred Kaltenbacher
University of Erlangen
Erlangen, Germany

Time: 6:00 pm - 10:00 pm, October 5, 2003

Abstract: The development of electromechanical transducers, such as piezoelectric ultrasound transducers, micromachined silicon sensors or, actuators based on electromagnetic transducing principles, e.g. electroacoustic magnetic transducers (EMATs), is a difficult task in general. Due to their high number of free parameters which have to be chosen right in order to come to an optimum design, precise computer simulations based on finite elements (FE) or boundary elements (BE) are often utilized within the design process. In the first part of that course, the theory of appropriate FE and BE schemes allowing the modeling of electromechanical coupled field problems as well as basic examples for piezoelectric, electrostatic and magnetomechanical transducers will be reviewed. The second part will focus on present real life applications. Therefore, the practical computer aided design of piezoelectric sensors and actuators, especially ultrasound antennas for imaging purposes, smart piezoelectric structures, micromachined capacitive sensors and actuators, micromachined capacitive ultrasound transducers (cMuts), micromechanical systems (MEMS) and, electromagnetic transducers like electrodynamic loudspeakers or EMATs will be demonstrated. The main goal of this course is to give a basic understanding of finite element transducer modeling as well as the know-how for its practical application to modern transducer design. A brief report on latest research regarding the determination of material parameters is also presented. Here, recent approaches based on a combination of measurements and simulations have led to significant enhancements. Finally, practical examples will be performed on a PC, therewith demonstrating that with nowadays simulation software even complex simulation tasks can be performed within reasonable time on low-cost hardware.

Reinhard Lerch received his master degree in 1977 and his Ph.D. degree in 1980 in Electrical Engineering from the Technical University of Darmstadt, Germany. From 1981 to 1991, he was employed at the Research Center of Siemens AG, where he introduced new computer tools supporting the design and development of piezoelectric transducers. Dr. Lerch is author or coauthor of more than 100 papers in the field of electromechanical sensors and actuators, acoustics and, signal processing. He received several scientific awards for his innovative work in the field of computer modeling of electromechanical transducers. From 1991 to 1999, he had a full professorship for Mechatronics at the University of Linz, Austria. Since September 1999 he is head of the Department of Sensor Technology at the University of Erlangen-Nuremberg. His current research is directed towards establishing a computer aided design environment for electromechanical sensors and actuators, including all major transducing principles. Dr. Lerch is serving on Technical Program Committees of several Technical Conferences. He is a member of the IEEE, the German Society of Electrical Engineers (VDE), the German Acoustical Society (DEGA), as well as the Acoustical Society of America (ASA).

Manfred Kaltenbacher received his Dipl.-Ing. in Electrical Engineering from the Technical University of Graz, Austria in 1992 and his Ph.D. in Technical Science from the Johannes Kepler University of Linz, Austria in 1996. He is currently an Associate Professor at the Department of Sensor Technology at the Friedrich-Alexander University of Erlangen. Dr. Kaltenbacher is author and coauthor of more than 30 papers in the field of numerical simulation techniques for coupled field problems and the identification of material parameters. His research interests are Computer Aided Engineering of electromechanical sensors and actuators with special emphasis on numerical simulation techniques such as multigrid methods. Furthermore, he is working on numerical algorithms that enable a precise and automatic reconstruction of material parameters from relatively simple measurements. Dr. Kaltenbacher is a member of the IEEE Society, ÖVE Society and the International Compumag Society.

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Course #9: Elasticity Imaging
Instructor: Stanislav Emelianov
University of Texas
Austin, Texas

Time: 6:00 pm - 10:00 pm, October 5, 2003

Abstract: Elasticity imaging is rapidly evolving into a new diagnostic and treatment-aid tool. The primary purpose of this course is to provide both a broad overview and comprehensive understanding of elasticity imaging, and, as such, it is well suited for both newcomers and active researchers in the field. Following a brief historical introduction to elasticity imaging, the analysis begins with a discussion of both the equation of equilibrium and the wave equation to lay a foundation for static (reconstructive) and dynamic (shear wave) approaches in elasticity imaging, respectively. The theory of elasticity is presented in the context of the mechanical properties of soft tissues. Then, practical and experimental aspects of elasticity imaging will be discussed with emphasis on data capture and measurements of internal tissue motion induced by either internal or surface applied forces. Motion tracking algorithms will be introduced, and methods to increase and optimize signal-to-noise ratio in strain imaging will be overviewed. Finally, techniques to map elasticity and other mechanical properties of tissue will be presented and discussed. The course will conclude with a review of commonly used elasticity imaging techniques, including a discussion of the advantages and limitations of each approach, and a presentation of current and potential clinical applications.

Stanislav Emelianov received the B.S. and M.S. degrees in physics and acoustics in 1986 and 1989, respectively, from the Moscow State University, and the Ph.D. degree in physics in 1993 from Moscow State University, and the Institute of Mathematical Problems of Biology of the Russian Academy of Sciences, Russia. In 1989, he joined the Institute of Mathematical Problems of Biology, where he was engaged in both mathematical modeling of soft tissue biomechanics and experimental studies of noninvasive visualization of tissue mechanical properties. Following his graduate work, he moved to the University of Michigan, Ann Arbor, as a post-Doctoral Fellow in the Bioengineering Program, and Electrical Engineering and Computer Science Department. From 1996 to 2002, Dr. Emelianov was a Research Scientist at the Biomedical Ultrasonics Laboratory at the University of Michigan. During his tenure at Michigan, Dr. Emelianov was involved primarily in the theoretical and practical aspects of elasticity imaging. Dr. Emelianov is currently an Assistant Professor of Biomedical Engineering at the University of Texas, Austin. His research interests are in the areas of medical imaging for therapeutics and diagnostic applications, ultrasound microscopy, elasticity imaging, opto-acoustical imaging, acousto-mechanical imaging, and radiation pressure imaging.

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