IEEE
Magnetics Soceity Distinguished Lecture (2009)
30th January, 4
PM onwards, LT4, National University of Singapore
Biomedical
nanomagnetics : A spin through new possibilities
Kannan M. Krishnan, University of Washington, Seattle
Two
of the principal challenges in biomedical nanoscience and personalized medicine
are: a) the detection of disease at the earliest possible time prior to its
ability to cause damage (diagnostics and imaging) and b) delivering treatment
at the right place, at the right time whilst minimizing unnecessary exposure
(targeted therapy with a triggered release).
The former is dominated by optical methods, emerging “life on a chip”
systems and the versatile magnetic resonance imaging technology. The latter
remains an ongoing challenge.
In this context, we have
been developing multifunction platforms for therapy, diagnostics and imaging
based on functionalized, biocompatible, nanomagnetic molecular probes. Our work encompasses innovations in synthesis
and functionalization, controlled self-assembly, advanced characterization, a
wide-range of magnetic measurements and modeling to tailor their behavior for
high moment or high frequency applications and carrying out cytotoxicity and
biocompatibility studies. Currently, in vitro (magnetic separation and
diagnostic relaxometry), in vivo
(hyperthermia treatment of cancer, triggered drug delivery) and imaging (contrast enhancement in MRI and
the development of a novel magnetic particle imaging microscope) applications are
all being pursued.
This
first part of the lecture will include an overview of nanotechnology,
size-dependent magnetic behavior and the emerging field of biomedical
nanomagnetics. This will be followed by a comprehensive discussion of our
current work in these areas highlighting the fundamental principles behind our
research in the context of emerging technological and clinical opportunities.
Kannan
M. Krishnan
received his B. Tech in Mechanical Engineering from IIT, Kanpur (India) in
1978, his MS in Materials Science from SUNY, Stony Brook in 1980 and his Ph.D
in Materials Science from the University of California, Berkeley in 1984. He
subsequently held various scientific and teaching positions at Lawrence
Berkeley National Laboratory, UC Berkeley before joining the University of
Washington, in 2001, as the Campbell Chair Professor of Materials Science and
Adjunct Professor of Physics. He has also held visiting appointments at the
Hitachi Central Research Laboratory (Japan), Tohoku University, Danish
Technical University, University of Sao Paolo, University of Western Australia
and Indian Institute of Science.
Prof. Krishnan is well recognized for
both research and teaching. His many awards include the Guggenheim Fellowship
(2004), the Rockefeller Bellagio Residency Fellowship (2008), the Burton Medal
(Microscopy Society of America, 1992), Japanese Society for the Promotion of
Science Senior Scientist Fellowship (2002), the University of Washington,
College of Engineering Outstanding Educator Award (2004) and an appointment as
the Professor-at-large at the University of Western Australia (2006-8). He is a
Fellow of the American Association for the Advancement of Science and the
Institute of Physics (London), and has served on the editorial boards of the
Journal of Materials Science and Journal of Physics D: Applied Physics.
Prof.
Krishnan’s inter-disciplinary research interests are in magnetic nanostructures
and thin film heterostructures, biomedical nanomagnetics, oxide spin
electronics, advanced materials characterization and structure-property
correlations at relevant length scales. All the projects are vertically
integrated from the underlying science to their engineering (information
storage, MEMS, magnetoelectronic devices) and biomedical (diagnostics, imaging
and therapeutics) applications.
Contact
details of the speaker: Prof. Kannan M. Krishnan, Department of Materials
Science, University of Washington, Seattle, WA 98195-2120, USA; telephone:
1-206-543-2814; fax: 1-206-543-3100; e-mail: kannanmk@u.washington.edu.
Local
contacts: Dr. S.N. Piramanayagam, prem_SN@dsi.a-star.edu.sg
A/Prof. Ding Jun, msedingj@nus.edu.sg
For
location details, please visit https://www.street-directory.com/nus/campus2.cgi?lecture=LT4