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Abstract

Abstract: DESCRIPTION (Provided by applicant): Hepatitis C viral infection is the most common chronic bloodborne infection in the United States. There are about 36,000 new infections every year, and 25-30 percent of those infections are symptomatic. It is estimated that 3.9 million (1.8 percent) Americans have been infected. Chronic liver disease, which is caused by HCV infection, is the tenth leading cause of death among adults in the United States, accounting for approximately 1 percent of all deaths. To date, there is no efficient culture system available to evaluate the activity of compounds against HCV in vitro. To overcome this difficulty, surrogate animal viruses are being used, including bovine viral diarrhea virus, yellow fever virus, dengue virus, and banzi virus. We have identified a compound (ZX-2401) that shows a significant antiviral activity against these surrogate viruses. The overall scope of this application is to investigate the feasibility of this compound and its derivatives as potential inhibitors of HCV. The specific aims for these novel compounds include synthesizing ZX-2401 or derivatives as needed for the proposed studies, performing in vitro antiviral studies in HCV replicon system and cytotoxicity testing, performing studies in combination with IFN-alpha, and performing mechanism of action studies.

Thesaurus Terms:
antiviral agent, drug design /synthesis /production, drug screening /evaluation, hepatitis C virus
Flaviviridae, cytotoxicity, dengue virus, drug adverse effect, interferon alpha, replicon, yellow fever virus
chemical synthesis

Institution:	ZYMETX, INC.
	800 RESEARCH PKY, STE 100
	OKLAHOMA CITY, OK 73104
Fiscal Year:	2002
Department:
Project Start:	01-JUN-2002
Project End:	30-JUN-2003
ICD:	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
IRG:	ZRG1