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| Grant Number: | 1R43AT001580-01 |
| PI Name: | CATTANEO, MAURIZIO V. |
| PI Email: | mcattaneo@ivrea.biz |
| PI Title: | |
| Project Title: | Intraarticular injection of polyglucosamine for knee OA |
Abstract: DESCRIPTION (provided by applicant): Osteoarthritis (OA) is a common disabling disorder for which no good medical remedy currently exists. As a result, many patients take Glucosamine, a nutritional supplement, for the treatment of their OA symptoms, because of its high level of safety compared to traditional anti-inflammatory medications. However, oral glucosamine is promptly metabolized by the liver during first-pass metabolism. Injectable polyglucosamine (PGA) is a highly viscous sustained-release form of glucosamine which may prove a more efficient modality for delivering glucosamine to the joint. The overall goal of this proposed Phase I SBIR is to determine if intraarticular injections of PGA protect against the early stages of joint damage in a rabbit model of OA. The proposed specific aims include: (1) Create a surgical instability of the knee in 14 2 Kg NZW rabbits using a modification of the Hulth technique. (2) Administer the PGA-treated and control groups (n=7 each) 5 weekly injections of PGA or saline respectively into the unstable knee, and maintain the animals for an additional 7 weeks. (3) Examine the extent of lesions in a blind fashion using morphological, histological and biochemical evaluations.
Thesaurus Terms:
articular cartilage, drug screening /evaluation, glucosamine, injection /infusion, knee, osteoarthritis, slow release drug
antiinflammatory agent, cytoprotection, nonhuman therapy evaluation
alternative medicine, histology, laboratory rabbit
| Institution: | IVREA, INC. |
| 196 SAMOSET AVE | |
| QUINCY, MA 02169 | |
| Fiscal Year: | 2002 |
| Department: | |
| Project Start: | 30-SEP-2002 |
| Project End: | 31-MAR-2003 |
| ICD: | NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE |
| IRG: | ZRG1 |