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| Grant Number: | 1R43CA097851-01 |
| PI Name: | FAN, JIAN-BING |
| PI Email: | jfan@illumina.com |
| PI Title: | |
| Project Title: | High-Throughput Methylation Profiling System |
Abstract: DESCRIPTION (provided by applicant): This proposal aims to develop a robust and ultra high-throughput technology for simultaneously assaying methylation at many specific sites in a genome. The technology we aim to develop will be based on a bead-based optical fiber array platform. This system is capable of analyzing hundreds to thousands of samples per day, and generating more than a million genotypes per instrument per day. We aim to provide a system that will enable high-resolution methylation profiling in large numbers of samples. The technology developed in this proposal will provide a powerful tool not only for fundamental genomic research, but also for cancer biology studies, with potential application to cancer classification and diagnosis, and anti-cancer drug target identification and drug screening. PROPOSED COMMERCIAL APPLICATIONS: NOT AVAILABLE
Thesaurus Terms:
genome, high throughput technology, methylation, technology /technique development
CpG island, DNA, computer program /software, computer system design /evaluation, genetic polymorphism, genotype, neoplasm /cancer genetics, robotics, tumor suppressor gene
clinical research, human genetic material tag, human tissue, immunomagnetic separation, nucleic acid probe, nucleic acid quantitation /detection, polymerase chain reaction
| Institution: | ILLUMINA, INC. |
| 9885 TOWNE CTR DR | |
| SAN DIEGO, CA 92121 | |
| Fiscal Year: | 2002 |
| Department: | |
| Project Start: | 01-JUL-2002 |
| Project End: | 31-DEC-2002 |
| ICD: | NATIONAL CANCER INSTITUTE |
| IRG: | ZRG1 |