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| Grant Number: | 1R43GM066464-01 |
| PI Name: | ZHU, LEYUN |
| PI Email: | zhu@psicorp.com |
| PI Title: | |
| Project Title: | Nanoprobes for Molecule-Specific Contrast Enhancement |
Abstract: DESCRIPTION (provided by applicant): Development of nano-Raman probes that will facilitate the detection of Raman scattering of individual molecule is proposed. The proposed phase I research will focus on the rational design of a nanoparticle system and analyte-nanoparticle complex. The nanoparticle-solid state support platform will also be optimized in the proposed research. During the phase I research the feasibility of a strategy for analyzing single molecule vibrational spectrum in complex cellular system will be established. This research will lead to the development of a marketable analytical system with the capability of analyzing the structure of an individual molecule. We believe that the availability of a robust sensitive Raman system will have broad interest from chemical and biomedical researchers. And it might have impact on DNA sequencing, early stage disease detection, and environmental monitoring.
Thesaurus Terms:
Raman spectrometry, nanotechnology, technology /technique development
colloid, high energy particle, light scattering, molecular dynamics, silver, thiol
| Institution: | PHYSICAL SCIENCES, INC. |
| 20 NEW ENGLAND BUSINESS CENTER | |
| ANDOVER, MA 01810 | |
| Fiscal Year: | 2002 |
| Department: | |
| Project Start: | 02-SEP-2002 |
| Project End: | 01-MAR-2003 |
| ICD: | NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES |
| IRG: | ZRG1 |