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| Grant Number: | 1R43HG002572-01 |
| PI Name: | ZHAO, LUE P. |
| PI Email: | lzhao@fhcrc.org |
| PI Title: | ASSOCIATE MEMBER |
| Project Title: | Gene Expression Data Analysis for Clinical Research |
Abstract: Our long-term goal for our newly formed bioinformatics company Enodar BioLogic Corporation (EBC) is to bring rigorously developed statistical tools to clinical genomic studies by marketing a software module called GENECLINIC. In the short-term, we will investigate the performance of a regression manifold of heterogeneous generalized linear models (HGLMs) in clinical genomic studies. If promising, we will develop HGLMs into a working prototype of GENECLINIC. GENECLINIC will associate gene expression with clinical outcomes, facilitating discovery of biomarkers for assessing efficacy of clinical treatment and prognosis. Phase I specific aims are to: 1) develop and test HGLMs for modeling clinical outcomes with expression profiles and 2) develop a user-friendly GENECLINIC software prototype module. GENECLINIC will have a key advantage over visualization tools and clustering methods by enabling clinical investigators to postulate and test specific genome-wide hypotheses under rigorous statistical assessment.
Thesaurus Terms:
clinical research, computer data analysis, computer program /software, computer system design /evaluation, gene expression, genetic mapping, informatics, prognosis
computer human interaction, computer simulation, mathematical model, microarray technology, statistics /biometry
human genetic material tag
| Institution: | ENODAR BIOLOGIC CORPORATION |
| 1100 OLIVE WAY, STE 1150 | |
| SEATTLE, WA 98109 | |
| Fiscal Year: | 2002 |
| Department: | |
| Project Start: | 07-JUN-2002 |
| Project End: | 06-MAR-2003 |
| ICD: | NATIONAL HUMAN GENOME RESEARCH INSTITUTE |
| IRG: | ZRG1 |