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Abstract

Abstract: DESCRIPTION (provided by applicant):InLight Solutions is actively developing a compact, robust, noninvasive acid-base status monitor that rapidly assesses patient acid-base status at the point-of-care. We have proven technical feasibility of the technique through in vitro studies using human blood samples. In these studies, our instrument measured pH, bicarbonate ion, and pC02 with clinically relevant accuracies. The proposed Phase I study will establish clinical feasibility for the noninvasive in vivo measurement of acid-base status in animals with an advanced research prototype that employs the Company's custom spectrometer. Elements of the study include (1) identifying the most suitable optical measurement site in the animal model using a laser Doppler instrument, (2) optimizing the data processing algorithms that isolate the arterial (pulsatile) component of broadband NIR tissue spectra, and (3) assessing the accuracy and precision of the noninvasive acid-base status monitor across the pathophysiological range of acid-base parameters. InLight Solutions intends to leverage its considerable experience in the area of noninvasive glucose monitoring to increase the probability of success in moving from in vitro to invivo acid-base measurements.

Thesaurus Terms:
acid base balance, biomedical equipment development, diagnosis design /evaluation, fiber optics, noninvasive diagnosis, spectrometry
acidity /alkalinity, bicarbonate, carbon dioxide, computer program /software, glucose, infrared radiation, patient monitoring device, ultrasound
swine

Institution:	INLIGHT SOLUTIONS, INC.
	800 BRADBURY SE, STE 217
	ALBUQUERQUE, NM 87106
Fiscal Year:	2002
Department:
Project Start:	23-SEP-2002
Project End:	22-AUG-2003
ICD:	NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
IRG:	ZRG1