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| Grant Number: | 1R43NS043039-01A1 |
| PI Name: | WANG, YUQIANG |
| PI Email: | yuquangwang2001@yahoo.com |
| PI Title: | |
| Project Title: | Novel NMDA Receptor-Binding Drugs for Ischemia/Stroke |
Abstract: DESCRIPTION (provided by applicant): The overall goal of this project is to develop a novel therapy for neurological injury. The concept is to combine two mechanisms known to provide neuroprotection from ischemic damage. Thus, we will combine a nitrone, known to have potent free radical scavenging activity with memantine, an open channel, uncompetitive NMDA receptor inhibitor, with demonstrated neuroprotective benefit in human clinical trials. In this proposal, we will synthesize novel dual functional memantine nitrones, demonstrate their neuroprotective effects both in vitro and in a rodent cerebral ischemia mice model. Based on these studies we are confident that this work will produce neuroprotective agents useful in neurodegenerative conditions such as stroke, epilepsy, trauma, and Alzheimer's disease, in addition to AIDS dementia. PROPOSED COMMERCIAL APPLICATION: A novel drug therapy for ischemia/stroke has a substantial commercial market.
Thesaurus Terms:
NMDA receptor, amantadine, cerebral ischemia /hypoxia, drug design /synthesis /production, neuroprotectant, nitrone, receptor binding, stroke
antiparkinson drug, drug screening /evaluation, free radical scavenger
electrophysiology, laboratory mouse, voltage /patch clamp
| Institution: | PANORAMA RESEARCH, INC. |
| 2462 WYANDOTTE ST | |
| MOUNTAIN VIEW, CA 94043 | |
| Fiscal Year: | 2002 |
| Department: | |
| Project Start: | 01-SEP-2002 |
| Project End: | 28-FEB-2003 |
| ICD: | NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE |
| IRG: | ZRG1 |