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Abstract

Grant Number:	1R41DK065457-01
PI Name:	BJURSTEN, LARS M.
PI Email:	lburjsten@ljbi.org
PI Title:	PROFESSOR BIOIMPLANT RESEARCH
Project Title:	Anti Inflammatory Membranes for Implantable Biosensors

Abstract: DESCRIPTION (provided by applicant): The prolonged inflammatory response to an implant is one of the primary causes for the failure to integrate implanted devices into tissue. The source of inflammation common to almost all implants is the foreign body response. Based on evidence in the literature and from our research team, the inflammatory response is mediated by the reactive oxygen species generated by macrophages, leukocytes, and the surrounding connective tissue. Based on our published findings, it is evident that titanium dioxide, even when present as surface coatings of polymeric biomaterials, has the ability to breakdown reactive oxygen species that have been identified as mediators of the inflammatory response. One device where the inflammatory response dramatically limits its clinical usefulness is the implanted glucose sensor. Here, there is a progressive loss of sensitivity caused by non-vascular fibrous tissue encapsulation. We propose to modify three different types of membranes used for implantable glucose sensors, by micropatterning coatings of titanium dioxide.

Thesaurus Terms:
biomaterial compatibility, biomaterial development /preparation, biosensor, implant, surface coating
free radical oxygen, image processing, inflammation, leukocyte, macrophage, titanium, transplantation immunology
X ray spectrometry, atomic force microscopy, immunocytochemistry, laboratory rat, medical implant science, morphometry, scanning electron microscopy

Institution:	APPLIED TISSUE AND MATERIALS, INC.
	10675 INDIGO BLOSSOM LN
	SAN DIEGO, CA 92121
Fiscal Year:	2003
Department:
Project Start:	15-SEP-2003
Project End:	31-AUG-2004
ICD:	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
IRG:	ZRG1

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