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Abstract

Grant Number:	1R41EB000374-01A1
PI Name:	CLEARY, KEVIN R.
PI Email:	cleary@georgetown.edu
PI Title:	ASSOCIATE PROFESSOR
Project Title:	Software Toolkit for Image Guided Surgery

Abstract: DESCRIPTION (provided by applicant): This Phase I STTR application represents a partnership between a university-based research group (Imaging Science and Information Systems [ISIS] Center, Department of Radiology, Georgetown University) and a small business specializing in open-source software development (Kitware, Inc. of Clifton Park, NY). Over the past 1 1/2years, the ISIS Center has been developing a prototype image-guided surgery system called IGBiopsy to enhance the precision of instrument placement for minimally invasive abdominal interventions. This system incorporates a soon-to-be commercially available magnetic tracking system and specially designed needles whose tip position can be monitored. The software for this prototype is based on the Visualization Toolkit (VTK), an open-source software system developed and now supported by Kitware. This prototype software and hardware will be used as the starting point for the work proposed here. The specific aims are: 1. Integration. As a demonstration project, we will integrate the graphical user interface for image-guided abdominal interventions developed by Georgetown with the Insight Registration and Segmentation toolkit (ITK) developed by Kitware and others. 2. Pre-clinical evaluation. The software developed in Aim 1 will be evaluated in a pre-clinical study using a liver respiratory motion phantom already developed by Georgetown. The accuracy of the system in assisting the physician in placing a biopsy needle into a simulated liver lesion will be evaluated. These tests and Specific Aim 3 will also be used to evaluate the accuracy of the magnetic tracking hardware in the interventional suite. 3. Clinical evaluation. The system will be further evaluated using a cadaver study in the interventional suite. The accuracy of the system in assisting the physician in targeting selected points in the liver will be evaluated. If the Phase I work proposed here is successful, Kitware and Georgetown University will be in a position to develop an open-source software framework for image-guided surgery in a Phase II effort.

Thesaurus Terms:
biopsy, computer program /software, computer system design /evaluation, image guided surgery /therapy, surgery material /equipment
abdomen, biomedical equipment development, bronchomotion, computer assisted patient care, computer graphics /printing, liver, surgical wound
bioimaging /biomedical imaging

Institution:	KITWARE, INC.
	469 CLIFTON CORPORATE PKY
	CLIFTON PARK, NY 12065
Fiscal Year:	2003
Department:
Project Start:	15-MAY-2003
Project End:	31-OCT-2004
ICD:	NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
IRG:	ZRG1

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