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Abstract

Grant Number:	1R41HL074535-01
PI Name:	FARRELL, DAVID H.
PI Email:	farrelld@ohsu.edu
PI Title:	PROFESSOR
Project Title:	Non-Immunogenic Peptide Anticoagulant

Abstract: We have identified a novel heparin-like peptidyl coagulation inhibitor that is a peptide fragment of a naturally-occurring human fibrinogen isoform, gammaA/gamma' fibrinogen. The peptide is active as an anticoagulant in whole plasma, and is unlikely to elicit an immune response, since it is a normal fibrinolytic cleavage product of this fibrinogen isoform. This application focuses on the development of this peptide as a potential pharmacologic anticoagulant. This peptide anticoagulant would have significant advantages over heparin, and could be used as a general replacement for heparin, particularly when heparin is clinically contraindicated, as in cases of heparin-induced thrombocytopenia. The specific aims are therefore to: I) Express the gamma' chain peptide in a recombinant expression system. II) Assay the recombinant gamma1,' peptide for anticoagulant and anti-platelet activities. At the conclusion of these studies, essential milestones will be achieved for Phase II development of the gamma' peptide as a pharmacologic anticoagulant.

Thesaurus Terms:
anticoagulant, biomaterial development /preparation, peptide, protein isoform
heparin, platelet
clinical research, human tissue

Institution:	BARLOW SCIENTIFIC, INC.
	6307 TAMOSHAN DR NW
	OLYMPIA, WA 98502
Fiscal Year:	2003
Department:
Project Start:	20-AUG-2003
Project End:	31-JUL-2004
ICD:	NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
IRG:	ZRG1

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