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Abstract

Grant Number:	1R42AG022805-01
PI Name:	GIULIAN, DANA
PI Email:	dgiulian@bcm.tmc.edu
PI Title:	PROFESSOR
Project Title:	Development of a transgenic rat to study brain aging

Abstract: DESCRIPTION (provided by applicant): Neuro-inflammation is thought to be an important factor in age-dependent loss of neuron associated with Alzheimer's disease. We seek STTR funding to develop a unique transgenic rat that serves as a model for chronic neuro-inflammation and age-dependent loss of neurons. Presently, no other animal model offers specific patterns of neuro-inflammation, presence of inflammatory cell-derived neurotoxins, and measurable age-dependent losses of neocortical neurons that closely match the pathology found in human brain during early AIzheimer's disease (AD). We believe that the novel rat model described here will have significant commercial potential among academic institutions and government agencies investigating mechanisms of AD pathology and among pharmaceutical and biotechnological companies testing drugs for treatment of AD.

Thesaurus Terms:
Alzheimer's disease, aging, brain, laboratory rat, technology /technique development, transgenic animal
amyloid protein, cognition, genotype, hippocampus, neocortex, neural degeneration, neuritic plaque, synapse
behavior test, histology, polymerase chain reaction

Institution:	INFLAME THERAPEUTICS, INC.
	8080 N STADIUM DR
	HOUSTON, TX 77054
Fiscal Year:	2003
Department:
Project Start:	30-SEP-2003
Project End:	31-AUG-2004
ICD:	NATIONAL INSTITUTE ON AGING
IRG:	ZRG1

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