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Abstract

Grant Number:	1R43AA014566-01
PI Name:	SCHLOSS, JOHN V.
PI Email:	ozcitizen@aol.com
PI Title:	CHIEF SCI OFCR, VP
Project Title:	Development of a Novel Agent for Alcohol Dependence

Abstract: DESCRIPTION (provided by applicant): Studies are proposed to complete the development of S-methyl N, Ndiethylthiolcarbamate sulfoxide (DETC-MeSO), a novel agents for the treatment of alcohol dependence. Specifically the following studies will be performed. 1. Complete the process chemistry development for DETC-MeSO and its Isomers. (carried out at Thiopharma, Inc) 2. Synthesize sufficient scale UP quantities for preclinical toxicology studies. (carried out at Pharm-Eco Laboratories, Inc) 3. Carry out pharmacokinetic studies in rats to support preclinical toxicology studies. (carried out at The University of Kansas) 4. Preclinical toxicology studies in rats and dogs. (carried out at Battelle).

Thesaurus Terms:
alcoholism /alcohol abuse, alcoholism /alcohol abuse chemotherapy, drug addiction, drug design /synthesis /production, sulfoxide, thiocarbamate
analytical method, disulfiram, method development, pharmacokinetics, toxicology
electrospray ionization mass spectrometry, laboratory rat, matrix assisted laser desorption ionization

Institution:	THIOPHARMA, INC.
	1256 QUAIL GARDENS CT
	ENCINITAS, CA 92024
Fiscal Year:	2003
Department:
Project Start:	25-SEP-2003
Project End:	31-MAR-2004
ICD:	NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
IRG:	ZAA1

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