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Abstract

Grant Number:	1R43AI052985-01A1
PI Name:	SEGAL, ANDREW H.
PI Email:	segal@genitrix.com
PI Title:
Project Title:	DNA Vaccines for Anthrax: Targeting Afferent Immunity

Abstract: DESCRIPTION (provided by the applicant): B. anthracis is a pathogen of major concern for national biodefense. DNA vaccines have a number of potential advantages in this context. However, they often elicit only modest immune responses. We will generate candidate DNA vaccines for anthrax that incorporate a proprietary technology which targets the afferent limb of the immune system, markedly amplifying the immune response. The technology may also accelerate the response. We will test our vaccines in non-infectious mouse models.

Thesaurus Terms:
Bacillus anthracis, anthrax vaccine, bacterial antigen, vaccine development, vector vaccine
anthrax, antigen antibody reaction, metalloendopeptidase
laboratory mouse

Institution:	GENITRIX
	160 SECOND ST
	CAMBRIDGE, MA 02142
Fiscal Year:	2003
Department:
Project Start:	15-APR-2003
Project End:	14-APR-2004
ICD:	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
IRG:	ZRG1

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