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Abstract

Grant Number:	1R43AR050302-01
PI Name:	PINNELL, SHELDON R.
PI Email:	spinnell@skinresearchinc.com
PI Title:	PROFESSOR
Project Title:	Photoprotection of Skin by Novel Polyphenol Antioxidants

Abstract: DESCRIPTION (provided by applicant): Novel derivatives of common plant polyphenol antioxidants have been synthesized. The compounds improve water and lipid solubility of the parent compounds, making them more suitable for topical application. The derivatives will be tested for their ability to photoprotect pig skin in vivo. Photoprotection will be measured as reduction in erythema, thymine dimer formation, apoptosis and signal transduction. After maximizing formulations for photoprotection, observations will be extended to human skin. The goal of this work will be to develop topical antioxidant formulations to protect human skin from skin cancer and photoaging changes.

Thesaurus Terms:
antioxidant, drug design /synthesis /production, photoprotection, skin
apoptosis, biological signal transduction, cysteine endopeptidase, erythema, thymine
high performance liquid chromatography, immunocytochemistry, swine, western blotting

Institution:	SKINRESEARCH, INC.
	BOX 13169
	RESEARCH TRIANGLE PARK, NC 27709
Fiscal Year:	2003
Department:
Project Start:	01-SEP-2003
Project End:	28-FEB-2004
ICD:	NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
IRG:	ZRG1

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