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Abstract
Grant Number: 1R43CA095935-01A2 PI Name: JALLAD, KARIM N. PI Email: jallad@purdue.edu PI Title: Project Title: In-Vivo Optical Imaging of Chemically Targeted Tumor Tis Abstract: DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I proposes the utilization of an in-vivo optical imaging system for tumor detection and localization during a laparoscopic surgery of ovarian cancer patients. Preliminary results using a prototype system demonstrated the effectiveness of folate-fluorescein to target specific tissues that express the receptor which is contained in greater than 90% of the ovarian cancers. The difference in fluorescence was very discernable. Tumors smaller than 1mm in size were noticeably fluorescent compared to background, thus the folate-fluorescein facilitated the detection of tumor tissues that were not detectable by direct observation, and would not be detectable by computed tomography (CT). Thus this technology is potentially a powerful and effective tool for monitoring patients with small volume ovary cancer with rising CA 125 levels after they have completed their primary surgery and chemotherapy. The need for such a technology is critical, since half of the patients who have advanced disease will suffer a recurrence in the first several years following completion of their primary therapy and the first sign of that recurrence is a rising CA 125 levels. At present, the CT imaging technology of choice is not sufficiently sensitive to detect tumors with a CA 125 level < 100 U/ml, or tumors smaller than about 1 cm. The primary aims of this Phase I proposal are i) to test the validity of this technology as an endoscopic fluorescent tumor imaging method and ii) to verify that human ovarian cancer tissues over-express the folate receptor. Thus this Phase I project is the basis for subsequent human medical trials to be carried out at the Indiana University Medical School in Phase II.
Thesaurus Terms:
biomedical equipment development, diagnosis design /evaluation, endoscopy, fluorescent dye /probe, folate, neoplasm /cancer diagnosis, optics, ovary neoplasm
biomarker, vitamin receptor
bioimaging /biomedical imaging, female, laboratory mouse
Institution: OPTICAL THERAPEUTIC TECHNOLOGIES, INC. PURDUE TECHNOLOGY CENTER WEST LAFAYETTE, IN 47906 Fiscal Year: 2003 Department: Project Start: 15-MAY-2003 Project End: 31-OCT-2003 ICD: NATIONAL CANCER INSTITUTE IRG: ZCA1
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