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Abstract
Grant Number: 1R43CA096292-01A1 PI Name: CHEN, CHANG-HUNG PI Email: cchen@vionpharm.com PI Title: Project Title: Identification of tumoricidal compounds in Salmonella Abstract: DESCRIPTION (provided by applicant): Attenuated Salmonella typhimurium accumulated and multiplied preferentially in tumors as compared to in normal tissues after being injected intravenously into tumor-bearing mice and rats. VNP20009, an attenuated strain with msbB-purl- deletions, is being evaluated in Phase I trials in cancer patients. VNP20009 induced significant tumor growth inhibition in addition to accumulated to high levels in tumors. Some of the closely related strains, however, did not inhibit tumor growth although they accumulated to similar levels, as did VNP20009. The main goal for this proposal is to evaluate differential protein expression in two pairs of bacteria and to identify components that cause tumor growth inhibition by combining the proteomic and genomic approach.
Thesaurus Terms:
Salmonella typhimurium, antineoplastic, biotherapeutic agent, drug discovery /isolation, protein quantitation /detection, protein structure function
attenuated microorganism, posttranslational modification, protein localization
protein purification, proteomics, two dimensional gel electrophoresis
Institution: VION PHARMACEUTICALS, INC. 4 SCIENCE PK NEW HAVEN, CT 06511 Fiscal Year: 2003 Department: Project Start: 01-FEB-2003 Project End: 31-JUL-2003 ICD: NATIONAL CANCER INSTITUTE IRG: ZRG1
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