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Abstract

Grant Number:	1R43CA101378-01
PI Name:	GIEDLIN, MARTIN A.
PI Email:	martin_giedlin@ceruscorp.com
PI Title:
Project Title:	Use of Listeria as Colon Cancer Vaccine Adjuvants

Abstract: DESCRIPTION (provided by the applicant): Colorectal cancer is the second leading cause of cancer death in the US. There is a 40 percent recurrence in patients treated surgically. Patients with distal metastatic disease have a low 5 yr survival rate with current chemotherapy. Therefore there is a critical need for improved options in the adjuvant setting. The principal goal of this SBIR Phase I proposal is to identify a panel of attenuated Listeria monocytogenes (Listeria) strains that can potentiate the immune response to cellular vaccines for colon cancer. Preliminary studies have suggested that Listeria administered following a therapeutic vaccination can target anti-tumor immune response specifically to liver metastases in a murine model of metastatic colon cancer, increasing the effectiveness of the vaccine by almost 5-fold. The various Listeria strains will be screened for relative pathogenicity and immunogenicity that characterize the innate and adaptive immune response. The immune response to these strains will also be assessed in the murine colorectal liver metastasis model. Appropriate attenuated strains of Listeria will be constructed to secrete GM-CSF and be evaluated for their ability to further augment the immune response to the vaccine in mice. Ultimately, this work will lead to novel adjuvant approaches to treating patients with advanced colon cancer.

Thesaurus Terms:
Listeria, attenuated microorganism, colon neoplasm, colony stimulating factor, immunomodulator, neoplasm /cancer vaccine, vaccine development
cytokine, liver neoplasm, metastasis, pharmacokinetics
laboratory mouse

Institution:	CERUS CORPORATION
	2411 STANWELL DR
	CONCORD, CA 945204810
Fiscal Year:	2003
Department:
Project Start:	01-APR-2003
Project End:	30-SEP-2003
ICD:	NATIONAL CANCER INSTITUTE
IRG:	ZRG1

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