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Abstract

Grant Number:	1R43CA103193-01
PI Name:	ZAMORA, PAUL O.
PI Email:	pzamora@biosetinc.com
PI Title:
Project Title:	Radioprotective mimetics of fibroblast growth factors

Abstract: DESCRIPTION (provided by applicant): We propose to develop and evaluate peptide mimetics of growth factors within the fibrobtast growth factor family. We have designed and produced the first ever synthetic multi-domain peptides, F2A3 and F2A4, that mimic natural FGF-2 and stimulate the biological activity of the FGF receptor. We will expand on this to build peptide mimetics of FGF-1 and FGF-7. The new variants will be evaluated and compared to their recombinant FGF counterparts as well as our current FGF-2 mimetics in a variety of biochemical and cellular assays.

Thesaurus Terms:
drug design /synthesis /production, fibroblast growth factor, peptide analog, radioprotective agent, synthetic peptide
biomimetics, growth factor receptor, protein engineering, receptor binding

Institution:	BIOSURFACE ENGINEERING TECHNOLOGIES
	387 TECHNOLOGY DR
	COLLEGE PARK, MD 20742
Fiscal Year:	2003
Department:
Project Start:	01-AUG-2003
Project End:	29-FEB-2004
ICD:	NATIONAL CANCER INSTITUTE
IRG:	ZRG1

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