Version 2.1.1.0

Abstract

Grant Number:	1R43EB001624-01
PI Name:	OLDENBURG, STEVEN J.
PI Email:	oldenburg@seashelltech.com
PI Title:
Project Title:	Nanofabricated Particles for Biolistic Delivery

Abstract: DESCRIPTION (provided by applicant): We propose the development of multi-functional composite particles for use as improved DNA delivery vehicles in biolistic applications. These particles will be fabricated using the controlled assembly of nanoparticles, polymers, and biomolecules via a layer-by-layer technique where the core and each subsequent layer add specific functionality to the final particle. The density, stability, surface area, and surface chemical composition will be controlled by the choice of material and dimensions of the core and surrounding shell layers. When these novel nano-fabricated devices are used in biolistic applications, the efficacy and reproducibility of the procedure will be greatly enhanced. These novel nanoparticles will be of broad interest to users of biolistic transfection systems in both academic and commercial research communities.

Thesaurus Terms:
DNA, biomaterial development /preparation, nanotechnology, particle
gene delivery system
biotechnology, cell line, electron microscopy, fluorescence microscopy, spectrometry, tissue /cell culture, transfection

Institution:	SEASHELL TECHNOLOGY, LLC
	3252 HOLIDAY CT, STE 227
	SAN DIEGO, CA 920371808
Fiscal Year:	2003
Department:
Project Start:	01-AUG-2003
Project End:	31-JUL-2004
ICD:	NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
IRG:	ZRG1

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