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Abstract

Grant Number:	1R43GM066465-01A1
PI Name:	GOLOVLEV, VAL V.
PI Email:	golovlev@aol.com
PI Title:	DIRECTOR OF RESEARCH AND DEVELOPMENT
Project Title:	BIOELECTRONIC MICROARRAY FOR DNA ANALYSIS

Abstract: In this project, we propose a new detection technology for identification of oligonucleotides, which works by detecting a bio-electronic response from hybridized duplexes. Compared with the conventional approach of using dye tagged oligos, the proposed electrochemical detector has significant advantages. Electrochemical sensing can be implemented using relatively simple equipment. Analysis can be performed in solution. In the proposed approach, no tagging of target molecules is required. When fully developed, highly integrated electronic chips, previously developed for imaging applications, can be modified and can be used as a new generation of inexpensive, disposable, electrochemical DNA microarray sensors.

Thesaurus Terms:
DNA, electrochemistry, microarray technology, nucleic acid hybridization, nucleic acid quantitation /detection, technology /technique development
consumable /disposable biomedical equipment, oligonucleotide
biotechnology

Institution:	SCI-TEC, INC.
	10425 COGDILL RD, #300
	KNOXVILLE, TN 379323395
Fiscal Year:	2003
Department:
Project Start:	01-APR-2003
Project End:	30-SEP-2003
ICD:	NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
IRG:	ZRG1

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