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Abstract

Grant Number:	1R43HG002696-01A1
PI Name:	BUCKLEY, JONATHAN D.
PI Email:	jbuckley@usc.edu
PI Title:	PROFESSOR
Project Title:	Integrated SNP, gene expression and proteomic analysis

Abstract: DESCRIPTION (provided by applicant): This project will see development of a software suite (Genetrix) comprised of tools for data management, visualization, machine learning, statistical analysis and biologic interpretation of data from the large-scale biological platforms (gene expression, SNP and proteomics), in conjunction with ancillary clinical, demographic, epidemiological, laboratory and outcome data. The bioinformatics challenges of the new large-scale biotechnologies and formidable: efficient mining of biologically- and clinically-relevant information requires coordinated contributions from computer scientists, statisticians, mathematicians, biologists and clinicians. The potential benefits however, are also substantial as evidenced by the rapidly growing use of gene expression rnicroarrays. The complexities, and payoffs, will increase dramatically as scientists begin to integrate SNP/proteomic data and gene expression data, and there will be demand for a new generation of software to meet this challenge. Genetrix will include algorithms to pre-process and normalize raw data to reduce noise, will provide a flexible, interactive and intuitive graphical interface, will support unsupervised and supervised for classification, and for dichotomous or survival outcome prediction, using appropriate statistic methods as well as proven machine learning heuristics, and will have extensive biological information integrated into the software, and available directly from Web resources.

Thesaurus Terms:
computer program /software, computer system design /evaluation, gene expression, genetic polymorphism, proteomics
artificial intelligence, data management, genetic screening, informatics, information system, mathematics
human data

Institution:	EPICENTER SOFTWARE
	BOX 90073, 935 LINDA VISTA AVE
	PASADENA, CA 91109
Fiscal Year:	2003
Department:
Project Start:	30-SEP-2003
Project End:	29-MAR-2004
ICD:	NATIONAL HUMAN GENOME RESEARCH INSTITUTE
IRG:	ZRG1

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