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Abstract

Grant Number: 1R43HL072589-01
PI Name: KINI, VINAYAK
PI Email: vinayak@fluent-csi.com
PI Title: PRESIDENT
Project Title: Improved Thrombolysis In Deep Venous Occlusions

Abstract: DESCRIPTION (provided by applicant): We have developed concepts for improving the efficiency of hydrolytic-aspiration type mechanical thrombectomy device (MTD) catheter systems for use in the treatment of thrombosed Hemodialysis Grafts (HDG). These improved systems are capable of providing higher shear-rates for thrombus maceration, with increased clot-aspiration potential and minimal potential for wall damage and distal embolization. The specific aim of this R&D project is to develop working prototypes of the catheter in order to validate all the design concepts and set the stage for further investments necessary to take the device into practical percutaneous thrombectomy use in the treatment of thrombosed HDG. In the first stage, we will extensively test the ability of the prototypes to generate high shear-rates and adequate aspiration potential under physiologic flow conditions with increased emboli-removal rates and reduced distal embolization. Successful development of proof-of-concept design prototypes will lead us to attempt to attract further funding for the in vivo trials needed to take the design into the HDG vascular surgery market.

Thesaurus Terms:
biomedical equipment development, cardiovascular surgery, fibrinolysis, shear stress, surgery material /equipment, venous thrombosis
blood flow measurement, cardiovascular imaging /visualization, computer simulation
bioengineering /biomedical engineering

Institution: FLUENT CARDIOVASCULAR SOLUTIONS, INC.
200 INNOVATION BLVD, STE 260
UNIVERSITY PARK, PA 16803
Fiscal Year: 2003
Department:
Project Start: 01-FEB-2003
Project End: 31-JUL-2003
ICD: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
IRG: ZRG1


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