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Abstract
Grant Number: 1R43HL073487-01 PI Name: DIENER, MICHAEL D. PI Email: mikee@tda.com PI Title: Project Title: Carbon Antioxidants To Prevent Atherosclerosis Abstract: DESCRIPTION (provided by applicant): Oxidation of low density lipoprotein (LDL) has been demonstrated to be a crucial early step in the process of arterial atheroma formation. As the atheroma grows and advances in development, the risk of death from myocardial infarction (MI) and stroke increases. It has therefore been proposed that supplemental antioxidants, which protect the LDL, should have therapeutic values against what is the leading cause of death in the United States. While copious in vitro studies have demonstrated that everything from vitamins to grape juice protects LDL from oxidation, in vivo studies using natural antioxidants with humans are less conclusive. There are needs for both a higher standard for in vitro testing and new antioxidant molecules. This project will study whether carbon-based antioxidants can extend their success to LDL protection and confer their benefits in vivo for retarding atherosclerosis.
Thesaurus Terms:
antioxidant, atherosclerosis, carbon, cardiovascular disorder prevention, drug screening /evaluation, low density lipoprotein
chemoprevention, copper, free radical oxygen, lipoxygenase, myeloperoxidase, oxidation, peroxynitrite
Institution: TDA RESEARCH, INC. 12345 W 52ND AVE WHEAT RIDGE, CO 800331916 Fiscal Year: 2003 Department: Project Start: 01-MAY-2003 Project End: 30-APR-2004 ICD: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE IRG: ZRG1
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