Version 2.1.1.0

Abstract

Grant Number:	1R43HL073548-01
PI Name:	SHNITSER, PAUL
PI Email:	sutama@poc.com
PI Title:
Project Title:	Multiwavelength Optical Coherent Endoscopic Oximeter

Abstract: DESCRIPTION (provided by applicant): The limitations of endoscopy for early diagnosis of ischemic colitis and other gastrointestinal diseases can be overcome by introducing new functions into the conventional endoscope. These functions allow noninvasively measuring blood flow and blood-oxygenation. To realize these options Physical Optics Corporate on (POC) proposes an innovative multiwavelength, optical coherence endoscope oximeter (MENDOXIM). It will be capable of measuring tissue oxygenation for tissue cross section to a depth of 1-3 mm with lateral width about 1 mm while providing a high-resolution morphological image of the same area. In Phase I, POC will test the prototype MENDOXIM on tissue phantoms and demonstrate its performance on a chicken embryo in laboratory conditions. Upon evaluation of the test results, POC will optimize the MENDOXIM design for developing a Phase II working prototype ready for tests on animal models.

Thesaurus Terms:
blood flow measurement, endoscopy, gastrointestinal disorder diagnosis, gastrointestinal imaging /visualization, optical coherence tomography, oximetry, respiratory oxygenation
gastrointestinal circulation, gastrointestinal circulation disorder, gastrointestinal circulatory insufficiency, hemoglobin
bioimaging /biomedical imaging, chick embryo, phantom model

Institution:	PHYSICAL OPTICS CORPORATION
	20600 GRAMERCY PL, BLDG 100
	TORRANCE, CA 905011821
Fiscal Year:	2003
Department:
Project Start:	01-JUN-2003
Project End:	30-NOV-2003
ICD:	NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
IRG:	ZRG1

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