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Abstract
Grant Number: 1R43NS043832-01A1 PI Name: FOWLER, WILLIAM V. PI Email: PI Title: DIRECTOR Project Title: Reduction of Cerebral Edema using Ventricular Therapies Abstract: DESCRIPTION (provided by applicant): Cerebral edema after traumatic brain injury and severe stroke is a life-threatening condition that is refractory to conventional treatments in a significant population of patients. Current treatments (i.e. hyperventilation, osmotic diuretic(s) or hypothermia) are associated with serious side effects that increase with prolonged use. Intracranial hypertension is caused by elevated tissue water content, primarily due to hyperosmosis of ischemic tissue. Thus, removal of water may be an effective treatment. The research plan details feasibility tests of a novel, safe, and effective method of removing water that can be placed within a standard ventriculostomy catheter. Pilot studies have shown a 50% reduction in water uptake by brain tissue in an ex vivo model. In vitro studies will be completed to optimize catheter material and design. Further ex vivo tissue studies will be completed, as well as studies of human post-traumatic CSF. Tissue water removal in a scale model of the human cerebroventricular system will be tested. The goal is to reduce edema in tissue samples without an increase in CSF osmolarity. Successful development and marketing of this proprietary methodology could significantly reduce morbidity and mortality after human TBI, stroke, and other neurological disorders associated with cerebral edema. In Phase II, further efficacy testing of catheter systems is planned in experimental models of cerebral edema and human studies.
Thesaurus Terms:
biomedical equipment development, body water dehydration, brain edema, brain injury, catheterization, osmosis, trauma
body fluid balance therapy, cerebrospinal fluid, vapor
clinical research, human subject
Institution: TWIN STAR MEDICAL 914 S 8TH ST, MC 860C ROSEVILLE, MN 55415 Fiscal Year: 2003 Department: Project Start: 01-JAN-2003 Project End: 30-JUN-2004 ICD: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE IRG: ZRG1