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Abstract

Grant Number:	1R43NS046177-01
PI Name:	NATARAJAN, ANANTH
PI Email:	ananth@i-biomed.com
PI Title:	CEO
Project Title:	Evoked Potential Monitor for Traumatic Brain Injury

Abstract: DESCRIPTION (provided by applicant): Traumatic Brain Injury (TBI) results in approximately 150,000 deaths per year in the United States. Most of the estimated 103,000 survivors are subjected to a prolonged hospital course and significant sequelae. TBI is associated with significant emotional distress for the patient and their family, and an economic burden of $48.3 billion per year to the nation. The consequences of TBI are rapid and devastating. There is a pressing need for reliable continuous neurological monitoring of such critical patients. Therefore, our Phase I goal is to investigate the use of quantitative Evoked Potential (qEP) analysis to detect and monitor the evolution of brain injury after TBI. We propose to develop a novel qEP system based on a powerful sinusoidal modeling algorithm known as ESPRIT. This system is intended to capture signal component changes due to injury. We will evaluate the ability of the qEP analysis to characterize acute cerebral injury, based on correlation with elevation of intracranial pressure and reduction of cerebral perfusion pressure in a rodent model. Further, we will observe the ability of qEP analysis to prognosticate the neurological outcome measured 72-hours after the introduction of an expansible mass lesion. If our Phase I effort is successful, we envision a Phase II effort focused on clinical validation of the technology. It is our long-term goal is to establish qEP analysis as a neurodiagnostic tool for improving the care of TBI victims.

Thesaurus Terms:
brain disorder diagnosis, brain injury, diagnosis design /evaluation, evoked potential, patient monitoring device, trauma
intracranial pressure, nervous system disorder diagnosis
laboratory rat

Institution:	INFINITE BIOMEDICAL TECHNOLOGIES, LLC
	2850 N CHARLES ST, STE 100
	BALTIMORE, MD 21218
Fiscal Year:	2003
Department:
Project Start:	01-SEP-2003
Project End:	31-AUG-2004
ICD:	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
IRG:	ZRG1

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