Version 2.1.1.0

Abstract

Grant Number:	2R44AI049026-02A1
PI Name:	DEDKOVA, LARISA
PI Email:	larisa.dedkova@pinnaclepharm.com
PI Title:
Project Title:	Identification of Antimicrobial Agents and Targets

Abstract: DESCRIPTION (provided by applicant): Antibiotics previously effective against pathogenic bacteria are rapidly being compromised by the spread of multiply resistant strains. In this Phase II program, Pinnacle Pharmaceuticals seeks to expand an assay system that has allowed the simultaneous identification of novel antibacterial compounds and of targets against which those compounds act. The Specific Aims of the present Phase II application are: 1. Specific Aim One: Purification and characterization of active principles derived from four target/inhibitor pairs elucidated in Phase I research. 2. Specific Aim Two: Target validation of the identified multicopy suppressing gene products using biochemical and bioinformatic approaches. 3. Specific Aim Three: Continued screening to identify new inhibitor/target pairs, resulting in characterized active principles for five of these new pairs.

Thesaurus Terms:
antibacterial agent, biological product, drug discovery /isolation, nucleic acid metabolism
bacterial genetics, drug screening /evaluation, high throughput technology, multidrug resistance, nucleic acid sequence, plasmid
guinea pig, laboratory mouse, tissue /cell culture

Institution:	PINNACLE PHARMACEUTICALS
	CHARLOTTESVILLE, VA 22911
Fiscal Year:	2003
Department:
Project Start:	01-JUN-2001
Project End:	31-JUL-2005
ICD:	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
IRG:	ZRG1

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