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Abstract

Grant Number:	2R44DE013892-02A1
PI Name:	KELLY-WINTENBERG, KIMBERLY K.
PI Email:	kwintenb@atmosphericglow.com
PI Title:	PRESIDENT & CEO
Project Title:	Eradicating Biofilms with Atmospheric Glow Plasma

Abstract: DESCRIPTION (provided by applicant): Atmospheric Glow Technologies proposes a novel method of cold sterilization and biofilm destruction of medical and dental materials. The effort will use the One Atmosphere Uniform Glow Discharge Plasma (OAUGDP) technology to attack and destroy biofilms, which cause serious problems on medical and dental instruments and devices. The use of atmospheric plasma to sterilize/decontaminate instrumentation contaminated with biofilms is a new application of a proven baseline technology. The efficacy of the OAUGDP using direct exposure was clearly demonstrated in Phase I studies. In this proposed effort, a remote atmospheric plasma reactor will be optimized to create a flow of concentrated reactive oxidative species (ROS) over 3-D workpieces and a novel direct plamsa delivery system for treating lumened devices. The performance of this reactor will be assessed against mixed species biofilms and in the presence of organic debris. Analytical studies will be undertaken to examine the composition of plasma ROS and any physical or chemical alterations that occur in materials and biological substances.

Thesaurus Terms:
biofilm, bioreactor, clinical biomedical equipment, disinfectant, physical state, radiowave radiation, technology /technique development
Pseudomonas aeruginosa, Staphylococcus aureus, atmospheric pressure, biomaterial compatibility, free radical oxygen, radiobiology
biotechnology, confocal scanning microscopy, laboratory mouse, mass spectrometry

Institution:	ATMOSPHERIC GLOW TECHNOLOGIES, LLC
	924 CORRIDOR PARK BLVD
	KNOXVILLE, TN 37932
Fiscal Year:	2003
Department:
Project Start:	01-SEP-2000
Project End:	31-MAY-2005
ICD:	NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
IRG:	ZRG1

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