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Abstract

Grant Number:	2R44GM062700-02
PI Name:	HUANG, CHIN-SHIOU
PI Email:	cshuang@aspirabio.com
PI Title:	CHIEF SCIENCE OFFICER
Project Title:	An Artificial Sequence-based Protein Receptor Array

Abstract: DESCRIPTION (provided by applicant): Our goal under this Phase II SBIR is to demonstrate that Protein Print TM Arrays can be effectively used for parallel expression profiling of biomarkers and novel therapeutic targets. As part of this work we will generate a commercially viable biomarker array for cancer research and diagnostics and optimize binding and detection conditions. During Phase I, we successfully generated arrays against six proof-of-principle proteins with diverse functions and properties. The cavities have high affinities (Kd ~ l nM) comparable to very good antibodies and specificity at the single amino acid level. This technology represents a breakthrough in our ability to study novel proteins with the potential to resolve the bottleneck in converting the wealth of genomic information into improved drug discovery.

Thesaurus Terms:
chemical structure function, intermolecular interaction, microarray technology, protein purification, protein sequence, proteomics, receptor, technology /technique development
acidity /alkalinity, gene expression, high throughput technology, informatics, intracellular transport, molecular shape, polymer, posttranslational modification, protein quantitation /detection
bioengineering /biomedical engineering, biotechnology, crosslink, fluorescence spectrometry, fluorescent dye /probe, peptide chemical synthesis

Institution:	ASPIRA BIOSYSTEMS, INC.
	571 ECCLES AVE
	SOUTH SAN FRANCISCO, CA 94080
Fiscal Year:	2003
Department:
Project Start:	01-SEP-2001
Project End:	31-JAN-2004
ICD:	NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
IRG:	ZRG1

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