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Abstract

Grant Number:	2R44GM064897-02
PI Name:	THUMAN-COMMIKE, PAMELA A.
PI Email:	pam@qedlabs.com
PI Title:	DIRECTOR OF RESEARCH
Project Title:	Software for Determination of Macromolecular Structures

Abstract: DESCRIPTION (provided by applicant): Macromolecular structure determination using electron microscopy has become a useful research tool aimed at understanding biological processes, identifying conformational changes, and characterizing components in cellular pathways. Our long-term goal is to broaden the group of people able to determine macromolecular structures by providing integrated, easy to use, and efficient software for routine determination of three-dimensional macromolecular structures using electron microscopy. To accomplish these goals, we will develop an add-on package, Single Particle Tumbleweed, to our existing Tumbleweed electron microscopy software suite. Novel aspects of this software include a system to guide users through the reconstruction process, multiple efficiently coded algorithms for macromolecular structure determination, and integrated data analysis and visualization tools. The software will provide a consistent, easy to use graphical user interface; data management, analysis, and logging tools; and extensive user help including tutorials. During this development work we will also enhance Tumbleweed with additional structural analysis capabilities, increased I/O performance, more robust data management, and the ability to run on commodity hardware. The result of this Phase II SBIR will be a complete design and implementation of this software package allowing easy, efficient, and routine determination of macromolecular structures by biomedical research scientists and structural biologists.

Thesaurus Terms:
cell component structure /function, computer program /software, computer system design /evaluation, electron microscopy, macromolecule, molecular dynamics, protein structure, structural biology, three dimensional imaging /topography
computer human interaction, conformation, data management
bioimaging /biomedical imaging

Institution:	QED LABS
	1190 S BASCOM AVE, STE 208
	SAN JOSE, CA 951263545
Fiscal Year:	2003
Department:
Project Start:	01-FEB-2002
Project End:	31-JAN-2006
ICD:	NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
IRG:	ZRG1

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