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Abstract

Grant Number: 2R44HL061994-02
PI Name: KRIVITSKI, NIKOLAI M.
PI Email: nikolai.krivitski@transonic.com
PI Title: STAFF SCIENTIST
Project Title: Cardiac Output for Children's ICU

Abstract: DESCRIPTION (provided by applicant):This proposal outlines the development of a minimally invasive cardiac output (CO) monitor for routine use for pediatric and neonatal patients in the intensive care unit setting. Presently, no technology is available for this use. Preliminary results using a prototype system in bench, animal, and in clinical trials demonstrated the potential accuracy and usefulness of this technology. The methodology presents the advantages of requiring only arterial and central venous access (no cardiac catheterization involve), use of innocuous isotonic saline as an indicator, no contact with the patients blood, and minimized indicator volumes administered to the patient. This method also provides the additional diagnostic information of septal defect identification and measurement of the blood volume in the heart, lungs, and great vessels. The objectives of this proposal are to develop new sensors to increase the capabilities of the system, to expand the data archive of CO dilution curves, to expand the use of the device to neonatal patients, to validate the system against thermodilution CO measurements, and to develop hardware that incorporates automatic control of a syringe pump that is used in the measurement.

Thesaurus Terms:
biomedical equipment development, cardiac output, intensive care, patient monitoring device, pediatrics, surgery material /equipment
clinical trial, computer system design /evaluation, indicator dilution test, ultrasound blood flow measurement
adolescence (12-20), child (0-11), clinical research, human subject, patient oriented research

Institution: TRANSONIC SYSTEMS, INC.
34 DUTCH MILL RD
ITHACA, NY 14850
Fiscal Year: 2003
Department:
Project Start: 01-NOV-1998
Project End: 28-FEB-2005
ICD: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
IRG: ZRG1


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