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Abstract
Grant Number: 2R44HL067014-02A1 PI Name: ROSEN, DAVID I. PI Email: rosen@psicorp.com PI Title: Project Title: MWIR Laser-Based Breath Sensor for Asthma Grading Abstract: DESCRIPTION (provided by applicant): Elevated levels of NO and CO in exhaled breath have been implicated as markers of airway inflammation in asthma. Combined with simultaneous measurements of exhaled CO2, Physical Sciences Inc. (PSI) proposes to develop a compact, low-cost sensor capable of dynamic, volume-resolved analysis of a single human breath. This capability will allow, for the first time, simultaneous measurements of expired NO and CO, as well as accurate resolution of upper airway, lower airway, and alveolar breath fractions. The sensor is based on advanced, room-temperature mid-IR tunable diode laser absorption. In the Phase I program, PSI demonstrated ppb-level detection of NO in human breath. In the Phase II program, we will integrate compact optical cell geometry with multiple lasers to develop and test a multi-species breath analyzer for asthma grading. The Phase II program will be conducted in partnership with Los Gatos Research and the Harvard Medical School's Brigham and Women's Hospital.
Thesaurus Terms:
asthma, biosensor, breath test, laser, technology /technique development
biomarker, breath composition, carbon dioxide, carbon monoxide, nitric oxide, pulmonary respiration, semiconduction
clinical research, human subject, mathematics, spectrometry
Institution: PHYSICAL SCIENCES, INC. 20 NEW ENGLAND BUSINESS CENTER ANDOVER, MA 01810 Fiscal Year: 2003 Department: Project Start: 10-SEP-2000 Project End: 31-MAY-2005 ICD: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE IRG: ZRG1
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