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Abstract

Grant Number:	4R44NS043105-02
PI Name:	RAGHAVAN, RAGHU
PI Email:	raghu@igneurologics.com
PI Title:
Project Title:	Systems for intra-parenchymal therapy delivery

Abstract: DESCRIPTION (provided by applicant): We are developing a suite of new computational methods to predict disposition of therapeutic agents directly injected into brain parenchyma. Our broad purpose is to develop a systems approach to site-specific delivery for brain diseases. We expect use in device design and selection, animal and pre-clinical testing, pre-operative planning, intra-operative controlled delivery, and post-operative monitoring. This fast track application aims to create (i) methods to validate models via in-vivo imaging (in Phase I), and (ii) a software product that can be used for predicting spatial distribution of intra-parenchymally injected molecules (in Phase II). The specific aims in Phase I are: (1) investigate MRI methods that can accurately assess the concentration of contrast agents in tissue when increase of water content and tissue edema can make quantitation difficult; and (2) propose methods to assess the resistance of brain tissue to the flow of injected fluid, including preferred directions of flow. Successful completion will enable assay of molecules in tissue in vivo for research. This will therefore have value well beyond the other aim, namely to provide the basis for validating software which will be developed in Phase II to serve as a critical pre-operative planning tool for all such deliveries in clinical practice.

Thesaurus Terms:
brain, drug delivery system, magnetic resonance imaging, technology /technique development
biotherapeutic agent, computer program /software, edema, gadolinium, injection /infusion, pharmacokinetics, vascular resistance

Institution:	IMAGE-GUIDED NEUROLOGICS, INC.
	600 WYNDHURST AVE, STE 305
	BALTIMORE, MD 21210
Fiscal Year:	2003
Department:
Project Start:	30-SEP-2003
Project End:	31-AUG-2005
ICD:	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
IRG:	ZRG1

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