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Abstract

Grant Number:	5R43AI051125-02
PI Name:	KAWAKAMI, YUKO
PI Email:	yuko_kawakami@liai.org
PI Title:
Project Title:	Tec inhibitors- A new therapeutic for allergic diseases

Abstract: DESCRIPTION (provided by applicant): The incidence of allergic diseases such as atopic dermatitis (AD) has been dramatically increasing in the US and other industrialized countries for the past two decades. We and others have demonstrated that Tec family protein-tyrosine kinases have crucial roles in the activation of immune cells elicited by the engagement of antigen receptors or Fc receptors. As such, these kinases are supposed to play critical roles in the pathogenesis of AD and other allergic diseases that involve the activation of T and B lymphocytes, mast cells, and eosinophils. We recently identified a small-molecule compound, terreic acid (TA), as a selective inhibitor of Tec family kinases. In addition, we recently established highly efficient experimental conditions to rapidly induce skin lesions in AD-prone NC/Nga mice. Using this mouse model, we propose to explore whether TA or related compounds are therapeutically efficacious as a treatment of AD. Since we have a screening method for searching for Tec inhibitors whose usefulness has been proven, we will also expand our search for better compounds.

Thesaurus Terms:
antibody receptor, antiinflammatory agent, atopic dermatitis, drug screening /evaluation, hypersensitivity, laboratory mouse, protein tyrosine kinase, quinone
enzyme inhibitor, leukocyte activation /transformation

Institution:	ALLIMMUNE, LLC
	10355 SCIENCE CENTER DR
	SAN DIEGO, CA 92121
Fiscal Year:	2003
Department:
Project Start:	01-AUG-2002
Project End:	31-JUL-2004
ICD:	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
IRG:	ZRG1

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