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Abstract

Grant Number:	5R43AI051905-02
PI Name:	GOULD-FOGERITE, SUSAN E.
PI Email:
PI Title:
Project Title:	Novel Adjuvants for HIV-Peptide Vaccines

Abstract: DESCRIPTION: (Provided by Applicant) This research program is a collaboration between a team of academic scientists who have developed an innovative HIV vaccine strategy, and a biotechnology company based upon a unique delivery vehicle, cochleates, that facilitates the oral delivery of drugs, antigens, and genes. The long term objective is to develop a unique, safe and effective prophylactic/therapeutic HIV subunit vaccine with the following advantageous characteristics: i- orally administered; ii- stable at room temperature; iiiinduces protective, HIV-specific, cell mediated immunity; iv- induces systemic and mucosal immune responses; and v- is inexpensive. The hypothesis upon which this SBIR Phase I research proposal is based is that oral administration of cochleate formulations containing a cocktail of synthetic HIV peptides will induce systemic helper and cytotoxic T lymphocyte responses in a mouse model. This hypothesis will be tested by performing the following specific aims: Aim 1: To determine which form of the synthetic peptides, plain or lipid tailed, induce the strongest CMI. Aim 2: To determine which structure of the delivery vehicle, liposome or cochleate, induces the strongest CMI. Aim 3: To determine the immunopotentiating effects of the SDE adjuvant/immunomodulator with these peptides. Aim 4: To characterize the immunogenicity of oral administration of the peptide-cochleate vaccine formulation. The overall study design will be to prepare the various peptide-adjuvant-delivery vehicle formulations, administer them to BALB/c mice, and assay for proliferative and cytolytic T cell responses.

Thesaurus Terms:
AIDS vaccine, cellular immunity, drug delivery system, immunomodulator, phospholipid, synthetic peptide, vaccine development, vector vaccine
HIV envelope protein gp160, calcium, lipid, liposome, mucosal immunity, oral administration
biotechnology, laboratory mouse

Institution:	BIODELIVERY SCIENCES INTERNATIONAL, INC.
	C/O UMDNJ NEW JERSEY MED SCHOOL
	NEWARK, NJ 071032757
Fiscal Year:	2003
Department:
Project Start:	15-AUG-2002
Project End:	31-JUL-2004
ICD:	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
IRG:	ZRG1

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