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Abstract

Grant Number:	5R44CA090095-03
PI Name:	MAGNESS, CHARLES L.
PI Email:	cmagness@illumigen.com
PI Title:
Project Title:	Automated Sequence Variation Analysis Software

Abstract: DESCRIPTION (provided by applicant): Phase II development of an automated DNA sequence variation analysis software package is proposed. The software analyzes diploid DNA sequencing and mixed methylation analysis samples from phenotypically stratified patient groups. The software package detects essentially all mutations of any type, and then classifies and scores them. The goals of this Phase II are to improve upon the successful Phase I implementation and complete the originally proposed development plan. This includes automated interpretation of mutations and methylation state and association of detected mutations with a phenotypic group. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

Thesaurus Terms:
automated data processing, computer assisted sequence analysis, computer program /software, computer system design /evaluation, data management, nucleic acid sequence
Barretts esophagus, CpG island, DNA methylation, Internet, gene mutation, genetic polymorphism, messenger RNA, molecular biology information system, phenotype
clinical research, human tissue

Institution:	ILLUMIGEN BIOSCIENCES, INC.
	2203 AIRPORT WY S, STE 450
	SEATTLE, WA 98134
Fiscal Year:	2003
Department:
Project Start:	01-APR-2001
Project End:	30-APR-2004
ICD:	NATIONAL CANCER INSTITUTE
IRG:	ZRG1

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