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Abstract

Grant Number:	5R44CA090178-03
PI Name:	SAIAKHOV, ROUSTEM
PI Email:	saiakhov@multicase.com
PI Title:
Project Title:	MCASE QSAR Expert System for Salmonella Mutagenicity

Abstract: DESCRIPTION (provided by applicant): Computational expert systems provide an inexpensive and fast alternative to short term genotoxicity assays such as the Ames test. Validation studies show the predictive capability of the MCASE system is about 85 percent. That is, 85 percent concordance is expected between experiment and computational genotoxicity predictions for new chemicals. The strong correlation between chemical structure and genotoxicity is particularly useful for 'in silico' prescreening of new drugs in the pharmaceutical industry. The new Salmonella database modules being developed in this work will be made available online to the public through the InfoTox web site (https://www.l-tox.com). Additionally, NIH grantees will be allowed unlimited access to the Salmonella modules through InfoTox at no cost. Collaboration will be sought with large drug companies, with mutual exchange of data. Thus the databases will evolve and improve over time as new data are submitted to form a centralized pool of mutagenicity data, that will provide a resource for avoiding unneeded testing of chemicals structurally similarly to those that are already thoroughly understood. Our collaborators at the FDA/CDER will lead the effort to build this industrial consortium. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

Thesaurus Terms:
Salmonella typhimurium, artificial intelligence, chemical information system, chemical structure function, computer simulation, computer system design /evaluation, informatics, mathematical model, mutagen testing
chemical property, gene mutation, high throughput technology, mutagen, physical property, toxicology
alternatives to animals in research, computer program /software, data collection, statistics /biometry

Institution:	MULTICASE, INC.
	23715 MERCANTILE RD, STE B104
	BEACHWOOD, OH 44122
Fiscal Year:	2003
Department:
Project Start:	08-FEB-2001
Project End:	31-MAR-2004
ICD:	NATIONAL CANCER INSTITUTE
IRG:	ZRG1

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