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Abstract

Grant Number: 5R44DK056561-03
PI Name: JANGHORBANI, MORTEZA
PI Email: mjanghor@uic.edu
PI Title:
Project Title: Accurate Noninvasive Test of Steatorrhea in Infants

Abstract: DESCRIPTION (provided by the applicant): The long-term objectives of this proposed project are to develop a "Test Kit" for quantitative assessment of steatorrhea in infants without the need for control of dietary fat intake and quantitative collections of stools for several days as is the case with the current "Gold Standard," viz, the 72-hour fecal fat method. Our proposed "Test Kit" is based on administering a feeding of infant formula containing a suitably labeled 13C-triglyceride (TG), a trace amount of the nonabsorbable marker dysprosium chloride (DyC1-3) and the visual marker Brilliant Blue followed by laboratory analysis of Dy and 13C-Excess in one or more sample(s) of stool containing the visual marker. The research conducted during Phase-I of this grant has led to the selection of 1,3-(13C-2) dipalmitoyl, 2-lauryl glycerol (P*LP*) as the most suitable TG* for applications in infants. During Phase II of the project, we propose to conduct clinical protocols with cystic fibrosis and healthy infants in order to: (1) define the parameters of the expected linear correlation between fecal excretion of P*LP* and fecal fat, (2) demonstrate the significance of this novel method in medical management of infants with steatorrhea, and (3) obtain research data necessary for the manufacture of a safe and noninvasive "Test Kit" for accurate assessment of steatorrhea in infants. The "Test Kit" has widespread applications in clinical management of infants with a wide range of disorders leading to steatorrhea.

Thesaurus Terms:
diagnosis design /evaluation, dietary lipid, gastrointestinal disorder diagnosis, infant human (0-1 year), lipid metabolism, malabsorption, noninvasive diagnosis, stable isotope diagnosis, steatorrhea, triglyceride
baby food, cystic fibrosis, dye, feces analysis, human milk, stable isotope
clinical research, human subject

Institution: BIOCHEMANALYSIS CORPORATION
2201 W CAMPBELL PARK DR
CHICAGO, IL 60612
Fiscal Year: 2003
Department:
Project Start: 01-SEP-1999
Project End: 30-JUN-2005
ICD: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
IRG: ZRG1


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