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Abstract

Grant Number:	5R44DK057395-03
PI Name:	CRAINE, BRIAN L.
PI Email:	blcraine@wrc-inc.com
PI Title:
Project Title:	Noninvasive Test For Management Of Nonulcer Dyspepsia

Abstract: DESCRIPTION (Applicant's abstract): Nonulcer dyspepsia is a highly prevalent medical condition affecting up to 30 percent of the Western population, accounting for 2-5 percent of all visits to primary care physicians and leads to over one billion dollars worth of upper endoscopy procedures per year. In an attempt to lower this tremendous burden on the health care system the general practice currently is to attempt to avoid endoscopy in the majority of patients, which are low risk, by an initial empiric trial of medication. Endoscopy can then be performed on those that fail initial therapy. Unfortunately, empiric treatment is only effective in about 40-50 percent of cases since it is difficult to determine in advance the most effective treatment. Consequently the high cost of endoscopy continues to be a problem. The overall goal of this project is to develop an inexpensive, non-invasive test for the objective and quantitative categorization of nonulcer dyspepsia patients with the purpose of providing the most effective initial treatment. The effectiveness of objective patient categorization will be tested with respect to ability to predict which patients will be responders to acid suppression therapy and which will be responsive to prokinetic treatment.

Thesaurus Terms:
diagnosis design /evaluation, gastritis, gastrointestinal disorder diagnosis, gastrointestinal sign /symptom, noninvasive diagnosis, ultrasonography
body physical characteristic, computer assisted diagnosis, inflammatory bowel disease, noise
clinical research, human subject

Institution:	WESTERN RESEARCH COMPANY, INC.
	2127 E SPEEDWAY, STE 209
	TUCSON, AZ 85719
Fiscal Year:	2003
Department:
Project Start:	01-NOV-1999
Project End:	31-JUL-2004
ICD:	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
IRG:	ZRG1

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