Version 2.1.1.0 CRISP Logo CRISP Homepage Help for CRISP Email Us

Abstract

Grant Number: 5R44GM063409-03
PI Name: RUBIN, DAVID M.
PI Email: david_rubin@cognia.com
PI Title:
Project Title: A Comprehensive Database Resource on Protein Catabolism

Abstract: DESCRIPTION (provided by applicant): This Phase II SBIR grant will enable the continued development of a unique and comprehensive research resource, the Protein Catabolism Database (PCDB), which will enable scientists to build upon a wealth of information to accelerate basic research and drug target identification. PCDB focuses on the field of protein catabolism, aberrations of which are implicated in cancer, neurodegeneration, inflammation, and immune disorders. During Phase I, a sophisticated classification system of proteolysis factors and substrates was devised, and a relational data structure created, complete with data input and retrieval interfaces. In Phase II, PCDB will be populated with comprehensive information on proteolysis pathways, and advanced interfaces for data mining and visualization will be created. The ultimate goal of PCDB is to provide academic and industrial investigators with carefully curated, up-to-date information on proteolysis, integrated with software tools to link specific knowledge to specific research problems. Completely unique applications will be developed, enabling targeting of pathogenic proteins through their proteolytic regulators, rational design of protein drugs with consideration of their in vivo half-lives. PCDB will also be novel in its ability to model drug effects on biological pathways, to differentiate complex biological states, and to accept user-generated curation. PROPOSED COMMERCIAL APPLICATION: The Protein Catabolism Database and its integrated software suite will have commercial application in industry and academia in the genome-wide prediction of proteolysis factors and substrates, tareting of proteins through proteolytic regulators, rational design of protein drugs with targeted in vivo half-lives, in silico modeling of pathogenic and drug-induced proteolytic pathways, and analysis of protein expression data elucidating pathogenesis and toxicology.

Thesaurus Terms:
biotransformation, computer program /software, computer system design /evaluation, data management, molecular biology information system, protein degradation, proteolysis
biomimetics, computer graphics /printing, enzyme mechanism, functional /structural genomics, informatics, information retrieval, protein engineering

Institution: COGNIA CORPORATION
117 E 55TH ST
NEW YORK, NY 10022
Fiscal Year: 2003
Department:
Project Start: 01-JUN-2001
Project End: 31-MAR-2004
ICD: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
IRG: ZRG1


CRISP Homepage Help for CRISP Email Us