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Abstract

Grant Number:	5R44HD039085-03
PI Name:	LEES, DAMON C.
PI Email:	damon@moberg.com
PI Title:	DIRECTOR OF RESEARCH
Project Title:	A Monitor to Assess Neurological Health in Neonates

Abstract: DESCRIPTION (provided by applicant): Many studies of neonates with a variety of conditions support EEG as a good prognostic indicator of outcome. However, the availability of expert neonatal EEG is very limited, available only at a relatively few specialized pediatric centers in the country. In addition, long-term monitoring of the EEG, which can provide the most accurate prognosis in neonates, is rarely used in clinical practice now because of the considerable effort required reviewing long-term data. This Phase II project will continue the development of accurate and reliable signal processing methods specific for analyzing and characterizing the background EEG in neonates. The objective is to develop an automated classifier of the background neonatal EEG that will agree with assessments made by clinical experts. The eventual goal is the development of a low-cost, easy-to-use monitor that can provide long-term continuous assessments of the neonatal background EEG. Such a monitor could be a good measure of treatment success, indicating neurological improvement or decline after treatment has been given. Also, it could impact level of care decisions, especially for those neonates given poor prognoses (e.g.: severe neurological deficits, or death).

Thesaurus Terms:
biomedical equipment development, diagnosis design /evaluation, electroencephalography, nervous system disorder diagnosis, newborn human (0-6 weeks), patient monitoring device
biological signal transduction, developmental neurobiology, electrode, electronic recording system, mother /infant health care
bioengineering /biomedical engineering, bioimaging /biomedical imaging, clinical research, human data

Institution:	MOBERG RESEARCH, INC.
	224 S MAPLE WAY
	AMBLER, PA 19002
Fiscal Year:	2003
Department:
Project Start:	01-AUG-2000
Project End:	31-JUL-2004
ICD:	NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
IRG:	ZRG1

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