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Abstract
Grant Number: 1R41DK076478-01A1 Project Title: Kidney Multiphoton Analysis of Therapeutic Agents
PI Information: Name Title DUNN, KENNETH WILLIAM. kwdunn@iupui.edu ASSOCIATE PROFESSOR Abstract: DESCRIPTION (provided by applicant): The integrated scientific team of INphoton, LLC will develop standard operating procedures for intravital multiphoton microscopy assays quantifying fluorescent drug delivery, cellular uptake, intracellular distribution, metabolism, and physiologic/therapeutic effects within the kidney of live rats. Refinement of some existing assays will be necessary for commercial utilization. The resulting products will enable INphoton to extend commercial services to pharmaceutical and biotech companies to enhance preclinical evaluation of potential products. INphoton, LLC will commercialize multiphoton microscopy for preclinical drug evaluation in the kidney. This will greatly aid evaluation of a potential therapeutic agent's cellular location, functional effects and adverse affects. Since this is not possible with other imaging modalities, this approach complements and extends existing imaging technologies.
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Institution: INPHOTON, LLC 1213 ALDERLEY RD INDIANAPOLIS, IN 462601622 Fiscal Year: 2007 Department: Project Start: 01-FEB-2007 Project End: 31-JAN-2008 ICD: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES IRG: ZRG1