Abstract
| Grant Number: | 4R44GM074437-02 |
| Project Title: | A Compact X-ray Station for Protein Crystallography |
Abstract:
DESCRIPTION (provided by applicant): The purpose of this Fast-Track SBIR is to develop an innovative Compact X-ray Station (CXS) for macromolecular crystallography. This station accepts the output x-ray beam of the Compact Light Source, a miniature synchrotron, and delivers x-ray beams to 3 end stations. Each beamline accommodates an integrated commercial diffractometer. Each of 2 side stations receives a tunable, monochromatic x-ray beam in a 30 micron rms spot. The forward station receives a focused higher-flux narrow band x-ray beam. Each of the x-ray beams is tunable from 7 to 16 keV and will provide a flux and energy resolution comparable to synchrotron beamlines. The beamlines can be run separately, in pairs or all 3 simultaneously. In Phase I, we will design the x-ray optics systems and experimentally test a new, tunable focusing monochromator. In Phase II, we will build the x-ray optics and end stations, integrate a commercial diffractometer and fully test the end stations. The CXS is an innovative, powerful, 'turn key' x-ray system which will provide a home laboratory with 3 'synchrotron' beamlines for macromolecular crystallography; 2 beamlines will have the flux, tunability, and energy resolution for single- or multi-wavelength anomalous dispersion experiments, and the third beamline will be optimized for higher-flux screening.
Thesaurus Terms:
X ray crystallography, biomedical equipment development, macromolecule, miniature biomedical equipment
electromagnetic radiation, optics, synchrotron
bioengineering /biomedical engineering
| Institution: | LYNCEAN TECHNOLOGIES, INC. |
| BOX 60910 |
| PALO ALTO, CA 943060910 |
| Fiscal Year: | 2006 |
| Department: | |
| Project Start: | 01-JUL-2005 |
| Project End: | 30-JUN-2008 |
| ICD: | NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES |
| IRG: | ZRG1 |
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